Autologous Bone Marrow Concentration for Femoral Shaft Fracture Union

Status Recruiting

Clinical Trial Summary

This study aims to evaluate the effect of bone marrow concentration on union of femoral shaft fracture by comparing clinical and imaging outcomes between patients receiving Intramedullary nail fixation with intraoperative bone marrow concentration and those receiving Intramedullary nail fixation only.

Clinical Trial Description

Femoral shaft fracture is a common orthopaedic injury. Intramedullary nail is one of the standard treatments. Its primary goal is to develop an osseous bridge between adjacent motion segments to prevent motion, relieve pain, and facilitate bone union. Delayed union or nonunion is common in femoral shaft fracture. Risk factors include comminuted fracture, open fracture, smoking, diabetes and open reduction of fracture fixation. Mesenchymal stem cells are pluripotent cells that can differentiate into multiple mesenchymal tissues, including tenocytes, chondrocytes and osteoblasts, as well as being a source of multiple growth factors to establish an environment conducive to soft and hard tissue regeneration. As bone marrow concentration has high concentration of mesenchymal stem cells, some studies have shown that autologous bone marrow concentration can improve bone healing. Therefore, the goal of this study was to evaluate the effect of bone marrow concentration on union of femoral shaft fracture. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03794622
Study type	Observational
Source	Show Chwan Memorial Hospital
Contact	Hsin-Chuan Chen, MD
Phone	+886975611139
Email	henang0424@gmail.com
Status	Recruiting
Phase
Start date	June 14, 2017
Completion date	December 2020

View Details

See also
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Not yet recruiting	`NCT05627479` - MAGIK for Femoral/Tibial Shaft Fractures	Phase 2
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Withdrawn	`NCT04803591` - This is a Study to Verify if Tranexamic Acid Can Reduce the Anemia After a Femoral Shaft Fractures Surgery	Phase 4
Terminated	`NCT01327508` - TRIGEN SURESHOT™ Distal Targeting System Study	N/A
Completed	`NCT00471913` - Functional Outcome and MRI of Muscle Damage Following Nailing Procedure in Femur (Thigh) Fractures Using Different Entry Points	N/A