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Bone Loss clinical trials

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NCT ID: NCT06424223 Not yet recruiting - Bone Loss Clinical Trials

Tunnel Access for Horizontal Alveolar Ridge Augmentation

Start date: June 1, 2024
Phase: N/A
Study type: Interventional

Minimally invasive procedures with the tunnel technique have been suggested to decrease patient post-operative discomfort and morbidity in oral bone regeneration. In the ridge augmentation tunnel technique, crestal incision and the release of the connective tissue are avoided in order to enhance the blood supply of the flap. This approach preserves the blood circulation and does not damage the periosteum The purpose of this study is to evaluate the clinical outcome of a minimally invasive technique for maxillofacial horizontal bone augmentation .

NCT ID: NCT06382974 Not yet recruiting - Infection Clinical Trials

Evaluation of the Osteoinductivity of Atorvastatin Combined With β-TCP

Start date: June 2024
Phase: N/A
Study type: Interventional

This case series study aims to evaluate the local effects of Atorvastatin (which belongs to the family of lipid-lowering drugs, known as statins) combined with β-TCP (which is a synthetic osteoconductive bone graft), on the volume of the residual bone defects and on hastening the bone regeneration after radicular jaw cyst enucleation using CBCT-based volumetric analysis to calculate the shrinkage rate of these defects.

NCT ID: NCT06323538 Not yet recruiting - Obesity Clinical Trials

Cohort Study on Plant-based Diets (COPLANT Study)

COPLANT
Start date: April 1, 2024
Phase:
Study type: Observational

The Cohort on Plant-based Diets (COPLANT) study is a multi-centre cohort study that starts baseline recruitment from 2024 to 2027 with approximately 6,000 participants in Germany and Austria. The COPLANT study focuses on vegan (no animal products), vegetarian (no meat and fish, but dairy products and eggs), pescetarian (no meat, but fish) and omnivorous (mixed diet including all possible animal products) diets. The aim of the COPLANT study is to gain new insights on health benefits and risks as well as social, ecological and economic effects of different plant-based diets in comparison to a mixed diet. In addition to a detailed dietary survey using an app adapted to the needs of this study, the baseline examination includes measurements of body composition, bone health, cardiovascular risk factors, diabetes risk, contaminants and lifestyle. For the basic laboratory program, fasting blood, 24-hour urine collection and a stool sample are taken from all study participants. Furthermore, specific aspects of dietary behavior, physical activity and other lifestyle factors are collected via questionnaires. Follow-up studies are planned at intervals of 5, 10 and 20 years after the baseline visit.

NCT ID: NCT06135441 Not yet recruiting - Bone Loss Clinical Trials

Bone Manifestation of Nutritional Disorders Among Infants and Pre-school Children

Start date: December 1, 2023
Phase:
Study type: Observational

Nutrients important to bones. Because bones undergo continuous remodeling, an adequate supply of nutrient substrate is needed to support the formation phase of bone remodeling. In addition to their passive roles as substrate for bone formation, dietary calcium and protein play active roles in bone metabolism, as well as phosphorus and vitamin D. Other vitamins and minerals are also needed for metabolic processes related to bone, directly or indirectly.

NCT ID: NCT06033989 Not yet recruiting - Bone Loss Clinical Trials

Clinical and Radiographic Evaluation of the Effect of Hyaluronic Acid Surface Treatment Versus Sandblasted Acid Etched on Stability of Delayed Dental Implant in Posterior Maxilla.

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

Clinical and Radiographic Evaluation of the Effect of Hyaluronic Acid Surface Treatment Versus Sandblasted Acid Etched on Stability of Delayed Dental Implant in Posterior Maxilla.

NCT ID: NCT05957926 Not yet recruiting - Bone Loss Clinical Trials

Hyaluronic Acid +Hydroxyapatite Vs Hydroxyapatite in Bone Regeneration

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

Evaluation of the effect of hyaluronic acid with hydroxyapatite versus hydroxyapatite alone on bone regeneration following enucleation of mandibular odontogenic cyst.

NCT ID: NCT05261334 Not yet recruiting - Bone Loss Clinical Trials

Socket Shield Technique Versus Early Implant Placement With Contour Augmentation

Start date: March 31, 2022
Phase: N/A
Study type: Interventional

comparing socket shield technique with early implant placement with contour augmentation in preserving the bone contour

NCT ID: NCT05066815 Not yet recruiting - Bone Loss Clinical Trials

Evaluation of Crestal Bone Loss Around Short Dental Implants As Affected By Two Suprastructure Materials

Start date: October 25, 2022
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the crestal bone loss developed around short dental implants after using screw retained Hybrid ceramic crowns when compare to screw retained Lithium Di silicate based ceramic crowns.

NCT ID: NCT04789759 Not yet recruiting - Bone Loss Clinical Trials

Biomaterial Clinical Performance in a Socket Preservation Model

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

When a dental extraction is performed, sequential cascade of events happens that lead to a modeling and remodeling of the area. This phenomenon leads to bone resorption and consequential volume loss atrophy. In literature several biomaterials (Autogenous, alloplastic, allografts and xenografts) were tested as alveolar fillers with the aim of controlling this physiologic event. Socket preservation is today a very widely spread dental technic to preserve the alveolar dimensions, that uses a wide range of biomaterials. Alloplastic materials have a fair evidence to work in several regenerative procedures in the oral and maxillofacial region. This pilot trial aims to characterize Histologic bone healing pattern in a human socket preservation model of 2/3 biphasic calcium sulfate cement matrix's and Hydroxyapatite (HA granules). Alterations in Volumetric alveolar socket changes in a socket preservation clinical model will also be studied.

NCT ID: NCT04670965 Not yet recruiting - Bone Loss Clinical Trials

Release Kinetics of rhBMP-2 Using E-PRF as an Autologous Carrier: An In Vitro Analysis

Start date: August 2024
Phase:
Study type: Observational

This study is seeking to evaluate the binding of a commercially-available, recombinant human osteoinductive growth factor, rhBMP-2, to a human blood derived product scaffold, enhanced Platelet-rich fibrin (E-PRF), and the release of such a growth factor over time in an in vitro (laboratory) environment. The investigators will compare these release kinetics to those of the FDA approved carrier for rhBMP-2, an absorbable collagen sponge (ACS), a combination of E-PRF and ACS, and E-PRF alone.