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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03286270
Other study ID # 002A/BT
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 1, 2017
Est. completion date April 27, 2018

Study information

Verified date June 2020
Source Bone Therapeutics S.A
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Early intervention attempts to shorten protracted delayed union (DU) or prevent non-union (NU) fractures are hampered by lack of validated quantitative assessment tools for bone fracture healing during normal and delayed healing processes. In actual practice, sequential X-rays usually follow a pre-determined time interval in patients with fractures.They constitute the best available state of the art used by surgeons to assess the fracture healing course.

In an attempt to improve between raters reliability of radiographic assessment of healing, studies have explored a novel radiographic assessment for tibial shaft fractures, the Radiographic Union Scale for Tibial Fractures (RUST). The RUST assesses the presence of bridging callus and a fracture line on each of four cortices (seen on anterior-posterior and lateral views). This callus based scoring system has been since extended to other bones than the tibia in a retrospective case series. It has been renamed modified radiological union score (mRUS) and has shown potential value in bone healing measurement.

Based on an initial retrospective study in nail-treated fractures, the first objective of the present investigation is to prospectively validate mRUS as a tool to identify patients at increased risk of DU and NU within the first 75-110 days after fracture occurrence. This prospective validation will be performed on a retrospective cohort of patients having sustained long bone fractures, including both upper and lower extremities. A further objective of the present investigation is to apply the scoring system to tomographic imaging in case of nail/plate treated fractures, deriving a tomographic union score (TUS) and first assess its potential value in bone healing for fractures treated by nails/plates.


Recruitment information / eligibility

Status Completed
Enrollment 173
Est. completion date April 27, 2018
Est. primary completion date April 27, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Male or female adult patient (>18 and < 80 years old)

- Patient with nail(s) (for mRUS validation study and TUS exploratory study) or plate(s) (for TUS exploratory study) treated long bone fractures, corresponding to the following OA/OTA classification: 11-A, 12-A, -B and -C, 13-A, 21-A, 22-A, -B and -C, , 31-A3, 32-A, -B and -C, 33-A 41-A2 and A3, 42-A, -B and -C and 43-A

- Patient for whom outcome of fracture is known

- For the mRUS validation study, patient with one follow up X-ray imaging performed 75-110 days after fracture occurrence

- For the TUS exploratory study, patient with one follow up CT-scan imaging performed 75-110 days after the fracture occurrence

Exclusion Criteria:

- Bone infection diagnosed between time of the fracture occurrence and the X-Ray or CT-scan imaging performed 75-110 days after the fracture occurrence

- Previous fracture and previous surgery on the fractured bone

- Bone tumour or history of bone tumour

- Bone metastasis

- Known evidence for ongoing metabolic bone disease (e.g. chronic renal failure, hyper or hypoparathyroidism, rickets, Paget's disease of bone, inherited or congenital bone abnormalities)

- Patient with current traumatic brain injury

Study Design


Locations

Country Name City State
Germany Investigating site DE01 Cologne
Germany Investigating site DE03 Lübeck
Germany Investigating site DE02 Munich
Germany Investigating site DE04 Würzburg

Sponsors (1)

Lead Sponsor Collaborator
Bone Therapeutics S.A

Country where clinical trial is conducted

Germany, 

Outcome

Type Measure Description Time frame Safety issue
Primary mRUS assessed on X-Ray 75-110 days after fracture occurrence
Secondary TUS assessed on CT-scan 75-110 days after fracture occurrence
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