A mRUS Validation Study for Nail-treated Fractures of Long Bones and a TUS Exploratory Study for Nail and Plate-treated Fractures of Long Bones

Bone Fracture Clinical Trial

— mRUSTUS  

Official title:

A mRUS Validation Study for Nail-treated Fractures of Long Bones and a TUS Exploratory Study for Nail and Plate-treated Fractures of Long Bones

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03286270
• Other study ID #: 002A/BT
• Status: Completed
• Start date: September 1, 2017
• Est. completion date: April 27, 2018

Study information

• Verified date: June 2020
• Source: Bone Therapeutics S.A
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Early intervention attempts to shorten protracted delayed union (DU) or prevent non-union (NU) fractures are hampered by lack of validated quantitative assessment tools for bone fracture healing during normal and delayed healing processes. In actual practice, sequential X-rays usually follow a pre-determined time interval in patients with fractures.They constitute the best available state of the art used by surgeons to assess the fracture healing course.

In an attempt to improve between raters reliability of radiographic assessment of healing, studies have explored a novel radiographic assessment for tibial shaft fractures, the Radiographic Union Scale for Tibial Fractures (RUST). The RUST assesses the presence of bridging callus and a fracture line on each of four cortices (seen on anterior-posterior and lateral views). This callus based scoring system has been since extended to other bones than the tibia in a retrospective case series. It has been renamed modified radiological union score (mRUS) and has shown potential value in bone healing measurement.

Based on an initial retrospective study in nail-treated fractures, the first objective of the present investigation is to prospectively validate mRUS as a tool to identify patients at increased risk of DU and NU within the first 75-110 days after fracture occurrence. This prospective validation will be performed on a retrospective cohort of patients having sustained long bone fractures, including both upper and lower extremities. A further objective of the present investigation is to apply the scoring system to tomographic imaging in case of nail/plate treated fractures, deriving a tomographic union score (TUS) and first assess its potential value in bone healing for fractures treated by nails/plates.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 173
• Est. completion date: April 27, 2018
• Est. primary completion date: April 27, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Male or female adult patient (>18 and < 80 years old)

• Patient with nail(s) (for mRUS validation study and TUS exploratory study) or plate(s) (for TUS exploratory study) treated long bone fractures, corresponding to the following OA/OTA classification: 11-A, 12-A, -B and -C, 13-A, 21-A, 22-A, -B and -C, , 31-A3, 32-A, -B and -C, 33-A 41-A2 and A3, 42-A, -B and -C and 43-A

• Patient for whom outcome of fracture is known

• For the mRUS validation study, patient with one follow up X-ray imaging performed 75-110 days after fracture occurrence

• For the TUS exploratory study, patient with one follow up CT-scan imaging performed 75-110 days after the fracture occurrence

Exclusion Criteria:

• Bone infection diagnosed between time of the fracture occurrence and the X-Ray or CT-scan imaging performed 75-110 days after the fracture occurrence

• Previous fracture and previous surgery on the fractured bone

• Bone tumour or history of bone tumour

• Bone metastasis

• Known evidence for ongoing metabolic bone disease (e.g. chronic renal failure, hyper or hypoparathyroidism, rickets, Paget's disease of bone, inherited or congenital bone abnormalities)

• Patient with current traumatic brain injury

Related Conditions & MeSH terms

• Bone Fracture
• CT-scan
• Delayed Union Fracture
• Fracture Healing
• Fractures, Bone
• Validation Studies
• X-Ray

Locations

Country	Name	City	State
Germany	Investigating site DE01	Cologne
Germany	Investigating site DE03	Lübeck
Germany	Investigating site DE02	Munich
Germany	Investigating site DE04	Würzburg

Sponsors (1)

Lead Sponsor	Collaborator
Bone Therapeutics S.A

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	mRUS assessed on X-Ray		75-110 days after fracture occurrence
Secondary	TUS assessed on CT-scan		75-110 days after fracture occurrence