Respiratory Muscle Contribution to Blood Pressure During Exercise

Blood Pressure Clinical Trial

Official title:

Respiratory Muscle Contribution to Blood Pressure During Exercise in Healthy Humans

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03514823
• Other study ID #: 17-011100
• Secondary ID: 5R01HL126638-03
• Status: Completed
• Phase: N/A
• Start date: August 1, 2018
• Est. completion date: September 25, 2019

Study information

• Verified date: July 2021
• Source: Mayo Clinic
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators seek to understand how reflexes from the breathing muscles influence blood pressure during exercise. Furthermore, the investigators are determining if increasing breathing muscle strength (via inspiratory muscle training) influences the respiratory muscle contribution to blood pressure during exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 38
• Est. completion date: September 25, 2019
• Est. primary completion date: September 25, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Healthy participants with no history of cardiovascular, pulmonary, neurologic, orthopedic or other neuromuscular diseases.

Related Conditions & MeSH terms

• Blood Pressure
• Exercise Capacity
• Respiratory Muscle
• Sympathetic Nerve Activity

Intervention

Other:
• Inspiratory Muscle Training (IMT)
Inspiratory muscle training (IMT) are breathing exercises used to increase strength and endurance of the respiratory muscles.
• No Inspiratory Muscle Training (IMT)
No inspiratory muscle training.

Locations

Country	Name	City	State
United States	Mayo Clinic	Rochester	Minnesota

Sponsors (2)

Lead Sponsor	Collaborator
Mayo Clinic	National Heart, Lung, and Blood Institute (NHLBI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	VO2 max test	Using a MedGraphics metabolic cart, the investigators will measure the maximum amount of oxygen that an individual can utilize during exercise. During this test the subject will be asked to exercise to his/her max capacity on a recumbent bicycle while breathing through a mouth piece that is hooked into the MedGraphics computer software.	Through study completion, an average of one year.
Primary	Blood Pressure	Blood pressure will be taken every few minutes during exercise testing using a standard blood pressure cuff to monitor changes in blood pressure.	Through study completion, an average of one year.

External Links

•   Mayo Clinic Clinical Trials