Clinical Trials Logo

Clinical Trial Summary

Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease(COPD),asthma and lung cancer.

Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to important societal concerns.

Identification of new biomarkers of exposure to tobacco smoke potentially implicated in COPD or lung carcinogenesis would allow a better observation of tobacco exposed population, thanks to screening establishment at reversible stages of pathological processes.

In this study, we question whether cigarettes smoking alters miRNA profiles of extracellular vesicles (EVs) present in human broncho alveolar lavages (BALs), which could affect surrounding normal bronchial epithelial cells status.


Clinical Trial Description

Extracellular vesicles (EVs) include a variety of nanoscale membranous vesicles (exosomes, microvesicles, microparticles). EVs are released into the interstitial fluid from a wide variety of normal or diseased cells.

Analysis of EVs and their content maybe useful as disease biomarkers as they reflect the contents of cells of origin, differ between normal and diseased tissue and can be reliably detected.

EVs may thus act as biomarkers of diverse pathologies like cancer, and detection of these biomarkers maybe applied to early diagnosis or assessment of prognosis in patients with cancer. EVs indeed contain both mRNAs and non-coding RNAs, such as small regulatory microRNAs (miRNAs). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03608293
Study type Interventional
Source Lille Catholic University
Contact
Status Completed
Phase N/A
Start date January 1, 2012
Completion date December 31, 2013

See also
  Status Clinical Trial Phase
Active, not recruiting NCT05095324 - The Biomarker Prediction Model of Septic Risk in Infected Patients
Recruiting NCT05548933 - Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
Active, not recruiting NCT03926572 - Acute Decompensation of Pulmonary Hypertension N/A
Recruiting NCT05372159 - Vanderbilt Memory and Aging Project
Completed NCT03173586 - Sugar Sweetened Beverage Intake and Biomarkers of Cardiometabolic Risk in US Women N/A
Completed NCT04554628 - Early Prediction of Acute Kidney Injury Among Patients Admitted to Surgical ICU N/A
Terminated NCT03250312 - The Effects of OMT on the Expression Patterns of Immune Cell Biomarkers N/A
Recruiting NCT04666766 - Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers N/A
Completed NCT04573543 - The Role of Immune Semaphorins in NAFLD
Completed NCT03193671 - Evaluation and Implementation of New Biomarkers and Algorithms for Diagnosis of Ovarian Cysts/Tumors in the Pelvis N/A
Recruiting NCT06047132 - PREDICTIVE ABILITY OF A PANEL OF BIOMARKERS IN SALIVA IN HEALTHY AND PERIODONTALLY AFFECTED SUBJECTS
Completed NCT05361460 - Patients Experiences of Early Postoperative Cognition
Recruiting NCT05706194 - Early Neuroprognostication After OHCA
Recruiting NCT05138731 - Metabolomics Profiling of Coronary Heart Disease
Recruiting NCT06446895 - Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
Not yet recruiting NCT04563000 - Impact of Vitamin C on Biomarkers of Neurologic Injury in Survivors of Cardiac Arrest Phase 2
Completed NCT05138692 - Biomarkers and Outcome 1 and 10-15 Years After Severe Traumatic Brain Injury
Completed NCT02247999 - Improving Cervical Cancer Screening Among HIV-Infected Women in India
Active, not recruiting NCT02732301 - Postoperative Gastrointestinal Dysfunction After Cardiac Surgery - Occurrence and Search for Biomarkers
Not yet recruiting NCT03269019 - Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia N/A