Bicuspid Aortic Valve Clinical Trial
Official title:
Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve
This study is to elucidate the impact of germline mutations and clonal hematopoiesis (CHIP) on the progression of early aortic valve calcification in patients with bicuspid aortic valves. The study will be conducted over a recruitment period of one year and a follow-up observation period of two years. Considering a 2-year event rate and a 33% occurrence rate of clonal hematopoiesis, each group requires a minimum of 102 participants. Accounting for a 15% dropout rate, a total of 120 participants are needed for each group (type I error (α) = 5%, type II error (β) = 20%). Therefore, the total study population, including patients with normal aortic valve function, is set at 240 participants.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT01390181 -
The Effect of Losartan in Bicuspid Aortic Valve Patients
|
N/A | |
Enrolling by invitation |
NCT06212050 -
Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis
|
||
Active, not recruiting |
NCT03635424 -
Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study
|
N/A | |
Active, not recruiting |
NCT03474159 -
Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging
|
N/A | |
Not yet recruiting |
NCT06375590 -
NavIIcusp: Bicuspid Aortic Valve Stenosis With Navitor Platform International Experience
|
||
Recruiting |
NCT05739253 -
Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement
|
||
Completed |
NCT01823432 -
Genetic Risks for Bicuspid Aortic Valve Disease
|
||
Completed |
NCT02679261 -
Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve
|
Phase 3 | |
Completed |
NCT01920815 -
Bicuspid Valve Aortopathy Feasibility Study
|
||
Recruiting |
NCT04817735 -
The CASPER Registry
|
N/A | |
Recruiting |
NCT02899624 -
Whole Exome Sequencing in Bicuspid Aortic Valve Patients
|
N/A | |
Recruiting |
NCT05708118 -
Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement.
|
||
Recruiting |
NCT03495050 -
BIVOLUTX: Bicuspid Aortic Stenosis With Evolut Platform International Experience.
|
||
Completed |
NCT01760668 -
Aortopathy in Persons With Bicuspid Aortic Valve, Turner and Marfan Syndrome
|
N/A | |
Not yet recruiting |
NCT05711693 -
Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)
|
N/A | |
Completed |
NCT05836363 -
Fate at Long-term of Mild to Moderate Bicuspid Aortic Valve Disease Left Untreated at the Time of Supracoronary Ascending Aorta Replacement
|
||
Completed |
NCT02283970 -
Investigation of Patients With BAV Requiring Valve and/or Aortic Repair (GISSI Outliers VAR)
|
||
Active, not recruiting |
NCT01026571 -
Identification of Genetic Causes of Bicuspid Aortic Valve Disease
|
||
Completed |
NCT00412386 -
Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve
|
N/A | |
Recruiting |
NCT03440697 -
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
|