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To Investigate the Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI)

Bacterial Infections Clinical Trial

Official title:
A Phase I, Randomised, Double-blind, 3-Part Study in Healthy Young and Elderly Subjects to Assess the Safety and Tolerability, and Investigate the Pharmacokinetics of Aztreonam and Avibactam Given Alone and in Combination (ATM-AVI)

Clinical Trial Summary

This is a randomised, double-blind, 3-part study designed to investigate the safety and tolerability of ATM-AVI. The study aims to characterise the pharmacokinetics of ATM-AVI, when both drugs are administered alone (ATM or AVI) and in combination (ATM-AVI), following single administration, and following multiple administrations of ATM-AVI in healthy male and female (females of nonchildbearing potential) volunteers both young and elderly.

Clinical Trial Description

A Phase I, Randomised, Double-blind, 3-Part Study in Healthy Young and Elderly Subjects to Assess the Safety and Tolerability, and Investigate the Pharmacokinetics of Aztreonam and Avibactam given Alone and in Combination (ATM-AVI) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01689207
Study type Interventional
Source Pfizer
Contact
Status Completed
Phase Phase 1
Start date September 2012
Completion date December 2014
View Details
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