Bacterial Infection Clinical Trial
Official title:
Exposure to NSAIDs (Non Steroidal Anti-Inflammatory Drugs) and Severity of Community-acquired Bacterial Infections
- NSAIDs are widely consumed, and some are currently available for self-medication with
indications 'Pain and Fever' (Cavalié, National Agency for Drug Safety (ANSM), 2014)
- There is no recommendation to limit their use in bacterial infections except for chicken
pox in children.
- To date, no study has highlighted the aggravating role of exposure to NSAIDs on
bacterial infections in adults, based on the usual septic severity Levy's score (SSS),
and mortality, but it delays adequate antibiotics (Legras, Critical Care, 2009)
- Community-acquired bacterial infections in adults exposed to NSAIDs are serious by their
spread (multiple locations), and suppurative character requiring frequent use of
invasive procedures such as surgery or drainage. The SSS does not reflect the
seriousness of these infections. They are frequently associated with use of ibuprofen
(63.4%), and self-medication practices (65.5%).
The main hypothesis is that NSAIDs exposure is associated with a specific severity of
community-acquired bacterial infection, marked by dissemination, suppurative complications or
even invasive procedures requirement.
Our objectives are also to:
- Describe what NSAID use terms are associated to the risk of serious bacterial
infections: molecule, dosage, duration of exposure, access (prescription or
self-medication), associated drugs.
- To determine what type (s) (s) of bacterial infection is worsened by exposure to NSAIDs.
- To determine if other risk factors contribute to severity of bacterial community
acquired infection
- To describe hospital costs associated to such severity of bacterial infection
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT02533609 -
Elimination of Antibiotics During Citrate-anticoagulated Continuous-veno-venous-haemodialysis
|
||
| Completed |
NCT01892358 -
Preventing Bacterial and Viral Infections Among Injection Drug Users
|
N/A | |
| Completed |
NCT01371656 -
Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation
|
Phase 3 | |
| Completed |
NCT01446289 -
Immune Response Induced by a Vaccine Against Group B Streptococcus and Safety in Pregnant Women and Their Offsprings
|
Phase 2 | |
| Completed |
NCT01059890 -
Cerebral Antibiotics Distribution After Acute Brain Injury
|
Phase 1 | |
| Completed |
NCT00389558 -
Antiseptic Use and Dressing Application
|
Phase 4 | |
| Completed |
NCT00760279 -
An Open Label Evaluation of the Pharmacokinetics and Safety of Single Dose Intravenous Azithromycin in Preterm Neonates
|
Phase 1 | |
| Completed |
NCT02311816 -
Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment in Critically Ill Patients
|
N/A | |
| Completed |
NCT01225042 -
The Effect of Probiotics on E. Coli Gastroenteritis
|
N/A | |
| Completed |
NCT00915213 -
Incidence of Antibiotic Resistant E.Coli in Patients Undergoing Repeat Prostate Biopsy
|
N/A | |
| Completed |
NCT00800488 -
Procalcitonin for Predicting Serious Bacterial Infection in Infants Less Than 3 Months
|
N/A | |
| Not yet recruiting |
NCT00765778 -
Mastering Hospital Antimicrobial Resistance and Its Spread Into the Community
|
N/A | |
| Terminated |
NCT00307099 -
Comparative Antibiotic Therapy for Subjects With Pulmonary Infiltrates in the ICU
|
Phase 3 | |
| Recruiting |
NCT04479657 -
Qingfei Granule for the Treatment of the Pediatric Acute Upper Respiratory Tract Infection With Bacterial Infection
|
Early Phase 1 | |
| Completed |
NCT03299894 -
Impact of qSOFA Calculation on the Timing of Antimicrobial Therapy in the Emergency Department
|
N/A | |
| Completed |
NCT01817075 -
Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant
|
Phase 3 | |
| Completed |
NCT01244698 -
Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction
|
Phase 4 | |
| Completed |
NCT01250574 -
Neutrophil CD64 and Procalcitonin as Novel Biomarkers for Postoperative Infections
|
||
| Completed |
NCT01012089 -
Study of the Pharmacokinetics of Daptomycin in Children With Renal Disease
|
N/A | |
| Withdrawn |
NCT00430469 -
Safety of hLF1-11 for the Treatment of Infectious Complications Among HSCT Recipients
|
Phase 1/Phase 2 |