A Pilot Study of Riluzole Versus Placebo in the Treatment of Children and Adolescents With ASD

Autism Spectrum Disorders Clinical Trial

— RILISE  

Official title:

A Pilot Study of Riluzole vs. Placebo in the Treatment of Children and Adolescents With Autism Spectrum Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01661855
• Other study ID #: RILISE-07-2013
• Status: Completed
• Phase: Phase 2
• First received: July 26, 2012
• Last updated: March 17, 2017
• Start date: September 2013
• Est. completion date: October 2015

Study information

• Verified date: March 2017
• Source: Anagnostou, Evdokia, M.D.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will examine the potential efficacy and safety of riluzole for core and associated symptom domains of autism and will explore biological markers of safety and treatment response.

Description:

There are no pharmacologic treatments available for social function deficits in individuals with Autism Spectrum Disorders (ASD). The data for pharmacologic treatment of repetitive behaviors in this disorder has also become difficult to interpret given that the last two large multisite trials of selective serotonin reuptake inhibitors (SSRIs) in autism are reported to be negative for the treatment of repetitive behaviors. Only the associated symptom of irritability has 2 drugs with FDA indications whereas no systematic data exists on the pharmacologic treatment of anxiety in ASD, and response to rates to stimulants for hyperactivity are lower than what is seen in attention deficit hyperactivity disorder (ADHD). In addition, there are no biological markers of treatment response identified in this population at this point. This study will examine the potential efficacy and safety of riluzole for core and associated symptom domains of autism and will explore biological markers of safety and treatment response.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 58
• Est. completion date: October 2015
• Est. primary completion date: September 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 6 Years to 17 Years

Eligibility

Inclusion Criteria:

1. Male or female outpatients 6-17 years of age inclusive, with a mental age equivalent = 18 months at Screening visit.

2. Meet Diagnostic and Statistical Manual (DSM-IV) criteria for an ASD.

3. Have a Clinician's Global Impression-Severity (CGI-S) score = 4 (moderately ill) at Screening.

4. If already receiving stable interventions must meet the following criteria:

1. If already receiving stable concomitant medications affecting behavior, must be on a stable dose during the preceding 1 month prior to Screening (with the exception of fluoxetine, where a period of 6 weeks is needed), and will not electively initiate new or modify ongoing medications for study duration.

2. If already receiving stable non-pharmacological educational, behavioral, and/or dietary interventions, have continuous participation during the preceding 3 months prior to Screening, and not electively initiate new or modify ongoing interventions for the duration of the study.

5. Have normal physical examination and laboratory test results at Screening. If abnormal, the finding(s) must be deemed clinically insignificant by the Investigator.

6. Ability to complete assessments- fluency in English (parent; patient, if verbal).

7. Consent to participate in the Province of Ontario Neurodevelopmental (POND) study and commitment to completing as many stages as possible of the phenotyping measures (Stages 1, 2 and 3), genomics component, and interest in being imaged through POND.

8. Ability to obtain written informed consent from the participant, if developmentally appropriate. If a participant does not have the capacity to consent, ability to obtain assent (if developmentally appropriate), as well as written informed consent from their parent(s)/legal guardian.

Exclusion Criteria:

1. Pregnant female patients; sexually active female patients on inadequate birth control.

2. Patients with a serious medical condition that, based on Investigator judgment, might interfere with the conduct of the study, confound interpretation of the study results, or endanger their own well-being. Patients with evidence or history of malignancy or any significant hematological, endocrine, cardiovascular (including any rhythm disorder), respiratory, renal, hepatic, or gastrointestinal disease, not including mild common pediatric diseases in these areas that are stable (e.g. mild asthma, constipation, etc.).

3. Patients with unstable epilepsy (i.e. seizures occurring within the last 6 months), or patients with epilepsy who are not on stable doses of antiepileptic medications (i.e. dose changes within the last 3 months).

4. Patients with hypersensitivity to riluzole or any components of its formulation.

5. Patients with one or more of the following: HIV, Hepatitis B virus, Hepatitis C virus, hemophilia (bleeding problems, recent nose and brain injuries), abnormal blood pressure (hypotension or hypertension), drug abuse, immunity disorder, major depressive episode or psychosis.

6. Patients unable to tolerate venipuncture procedures for blood sampling.

7. Patients receiving concomitant medications that specifically target the glutamate system (e.g. memantine, d-cycloserine), or decrease the elimination of riluzole (e.g. theophylline, quinolones), less than 30 days prior to the screening visit.

8. Patients actively enrolled in another intervention study.

9. Patients who are unable to swallow pills.

10. Patients who have elevated liver enzymes = 3 times the normal amount before the study begins.

Related Conditions & MeSH terms

• Autism Spectrum Disorder
• Autism Spectrum Disorders
• Autistic Disorder
• Child Development Disorders, Pervasive

Intervention

Drug:
• Riluzole
50mg once daily (QD) for 12 weeks for participants 6-11 years old; 50mg twice daily (BID) for 12 weeks for participants 12-17 years old
• Placebo
Placebo comparator once daily (QD) for 12 weeks for participants 6-11 years old; Placebo comparator twice daily (BID) for 12 weeks for participants 12-17 years old

Locations

Country	Name	City	State
Canada	Offord Centre for Child Studies	Hamilton	Ontario
Canada	Lawson Health Research Institute	London	Ontario
Canada	Holland Bloorview Kids Rehabilitation Hospital	Toronto	Ontario

Sponsors (7)

Lead Sponsor	Collaborator
Evdokia Anagnostou	Holland Bloorview Kids Rehabilitation Hospital, McMaster University, St. Michael's Hospital, Toronto, The Hospital for Sick Children, University of Toronto, University of Western Ontario, Canada

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Efficacy of riluzole vs. placebo on measures of social function	This will be measured by the Aberrant Behavior Checklist (ABC) - Lethargy / Social Withdrawal Subscale	12 weeks
Primary	Efficacy of riluzole vs. placebo on measures of repetitive behaviors	This will be measured by the Child Yale-Brown Obsessive Compulsive Scale (CY-BOCS)	12 weeks
Primary	Efficacy of riluzole vs. placebo on measures of repetitive behaviors	This will be measured by the Repetitive Behavior Scale (RBS-R)	12 weeks
Primary	Safety and tolerability of riluzole in children and adolescents with ASD	This will be measured by the Safety Monitoring Uniform Report Form (SMURF)	12 Weeks
Primary	Safety and tolerability of riluzole in children and adolescents with ASD	This will be measured by the Clinical Global Impressions - Improvement Scale - Global (CGI-I-Global)	12 Weeks