Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning

Autism Spectrum Disorder Clinical Trial

— PLAUSL  

Official title:

Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06332144
• Other study ID #: 1R56DC020208-01A1
• Status: Recruiting
• Start date: January 13, 2024
• Est. completion date: August 31, 2024

Study information

• Verified date: March 2024
• Source: Northeastern University
• Contact: Brynn Siles, BS
• Phone: 617-830-1530
• Email: plausl.project[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this observational study is to test a reciprocal relationship between statistical learning and the development of language and literacy in first-graders with autism and their non-autistic peers. The main questions it aims to answer are: 1. whether children's statistical learning abilities can predict their long-term improvement of language and literacy skills in school; 2. how children's brains automatically learn patterns from speech and prints; 3. whether children's learning in the lab reflects the language patterns they have learned over the years from their native language. First-grade students will participate in the study twice across three months. During Time 1, children will complete - a battery of language, reading, and cognitive assessments - a series of computer-based statistical learning games both inside and outside of functional MRI scanner. During Time 2, children will complete a battery of language and reading assessments to detect the growth in three months. Researchers will compare the autistic and the non-autistic groups to see if statistical learning plays a similar or different role in predicting children's language and literacy growth.

Description:

In this one-year R56 project, the investigators will design a mini-longitudinal project to test how children's linguistic statistical learning predicts their growth in spoken and written language in three months. The investigators predict that weaker linguistic statistical learning underlies the exacerbation of language and literacy delay in children with ASD. In this project, the investigators will gamify an existing study protocol, which has led to promising discoveries motivating the original R01 proposal. With an enriched platform, the investigators expect a low attrition rate (<10%) and few missing data (>90% task completion rate) in this longitudinal sample of six-year-olds both with and without ASD, matched on age and sex ratio. This project will lead to critical feasibility and preliminary data to support the key hypotheses of all three aims. Due to a shortened timeline, the investigators plan to recruit 25 children per group, sampled from a diverse population, to ensure the team's capacity for a three-month follow-up session before the end of a school year. Aim 1: Establish the longitudinal relationships between SL and language/literacy development in both TD and ASD. In this aim, the investigators will evaluate the role of SL in both concurrent and the growth of language/literacy skills assessed in three months during the school year. The investigators expect that linguistic SL (embedded pattern learning of syllables and letters) is associated with concurrent language and literacy skills and will prove to be crucial predictors of growth in language and literacy skills in both groups. Given the small sample size in this one-year project, the investigators will build prediction models both across the two groups and within each group. Sex, concurrent language and reading skills, and nonverbal IQ will be included as key covariables. Aim 2: Determine the longitudinal relationships between neural bases of SL and developing language networks in the brains of children with ASD. In this aim, the investigators will test whether altered brain functions during linguistic SL are related to poorly functioning language networks (language comprehension and phonological working memory), defined within each individual child. The investigators will also examine whether neural bases of linguistic SL predict future language and literacy development in children with ASD. Participants from Aim 1 will complete linguistic SL tasks and two well-validated language tasks in the fMRI scanner at Time 1. The investigators expect to find reduced engagement of language networks during SL in children with ASD and to provide a neurobiological explanation for the cascading effect impaired linguistic SL casts on future language development. Aim 3: Test whether linguistic SL is a proxy for children's sensitivity to real-world language statistics. The investigators ask whether the specific weakness in linguistic SL in ASD generalizes to real-world language statistics using serial recall tasks, a well-validated instrument for individuals' sensitivity to native-language statistical patterns. The same participants in the previous aims will complete a phonological and an orthographic serial recall task containing both high- and low-frequency English bigrams/trigrams at Time 1 and Time 2. The investigators predict that these tasks will be associated with children's linguistic SL performance in Aim 1 and children's linguistic SL at earlier times will predict the future growth of sensitivity to natural language statistics. These findings will establish the critical link between linguistic SL and children's natural language skills.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: August 31, 2024
• Est. primary completion date: August 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 72 Months to 90 Months

Eligibility

Inclusion Criteria:

• current first grader (6;0 - 7;6)
• Geographically located within the Greater Boston Metropolitan Area
• Native English speakers
• Right-handed
• Normal hearing
• Normal or corrected vision

Inclusion criteria for children with ASD (N = 25):

• Children with a professional diagnosis of autism according to expert clinical judgment
• Capable of speaking sentences with three or more words
• Social Communication Parent Questionnaire score > 15
• Autism diagnosis confirmed by ADOS

Inclusion criteria for typically developing controls (N = 25):

• Neurotypical: with no known cognitive, neurological, or psychiatric disorders
• Social Communication Parent Questionnaire score < 11
• Receive a score within 1 SD of the population mean for age on all assessments.

Exclusion Criteria:

• left-handed
• non-native speakers of English
• More than 30 hours of exposure to a language other than English per week
• history of brain injuries and head injuries
• intellectual disability, mutism, motor delay, or developmental coordination disorder
• metal in body
• claustrophobic
• history of prior neurosurgical procedure
• substance abuse
• signs of increased intracranial pressure

Related Conditions & MeSH terms

• Autism Spectrum Disorder
• Language Development
• Literacy

Intervention

Behavioral:
• Structural vs. Random sequences of stimuli
Participants will see or listen to sequences of sounds and images either in a structured condition or a random condition.
• Intact vs. Degraded speech
Participants will listen to an audiobook "Alice in Wonderland" in the MRI scanner. The speech is either intact or degraded.
• Repeating 5-syllable nonwords or 2-syllable nonwords
Participants will listen to nonwords (either 5-syllable or 2-syllable) and then repeat them as accurately as possible in the MRI scanner.
• Recall letter or syllable strings that either contain highly frequent bigram/trigram items or infrequent items according to English Corpus data.
Participants will read (orthographic serial recall) or listen to (phonological serial recall) strings.

Locations

Country	Name	City	State
United States	Boston University	Boston	Massachusetts
United States	Northeastern University	Boston	Massachusetts

Sponsors (4)

Lead Sponsor	Collaborator
Northeastern University	Boston University, Cornell University, University of Delaware

Country where clinical trial is conducted

United States, 

References & Publications (4)

Hu A, Kozloff V, Owen Van Horne A, Chugani D, Qi Z. Dissociation Between Linguistic and Nonlinguistic Statistical Learning in Children with Autism. J Autism Dev Disord. 2023 Feb 7:10.1007/s10803-023-05902-1. doi: 10.1007/s10803-023-05902-1. Online ahead of print. — View Citation

O'Brien AM, Perrachione TK, Wisman Weil L, Sanchez Araujo Y, Halverson K, Harris A, Ostrovskaya I, Kjelgaard M, Kenneth Wexler, Tager-Flusberg H, Gabrieli JDE, Qi Z. Altered engagement of the speech motor network is associated with reduced phonological working memory in autism. Neuroimage Clin. 2023;37:103299. doi: 10.1016/j.nicl.2022.103299. Epub 2022 Dec 23. — View Citation

Ozernov-Palchik O, Qi Z, Beach SD, Gabrieli JDE. Intact procedural memory and impaired auditory statistical learning in adults with dyslexia. Neuropsychologia. 2023 Sep 9;188:108638. doi: 10.1016/j.neuropsychologia.2023.108638. Epub 2023 Jul 28. — View Citation

Schneider JM, Hu A, Legault J, Qi Z. Measuring Statistical Learning Across Modalities and Domains in School-Aged Children Via an Online Platform and Neuroimaging Techniques. J Vis Exp. 2020 Jun 30;(160):10.3791/61474. doi: 10.3791/61474. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Neural activation to statistical regularities during the language tasks	The magnitude of BOLD responses to intact vs. degraded speech and 5-vs-2 syllable in the language and phonological working memory tasks	At the first visit during the school year of the first grade over a two-hour MRI session
Primary	Language Composite Score	The concurrent language skills will be computed by averaging each child's standardized scores across the TILLS language subsets and NIH Toolbox Picture Vocab. The composite score will range between 50 and 150. The higher score, the better language skills.	At each of the two measuring time points during the school year of the first grade with three months apart over a 40-minute teleassessment session
Primary	Reading Composite Score	The concurrent reading skills will be computed by averaging across WRMT-III subtests, NIH Toolbox oral reading recognition. The composite score will range between 50 and 150. The higher score, the better reading skills.	At each of the two measuring time points during the school year of the first grade with three months apart over a 40-minute teleassessment session
Primary	Language/Literacy Disorder Status	The binary status is determined by children's TILLS Identification core scores	At the first visit during the school year of the first grade over a 40-minute teleassessment session
Primary	Neural similarity between language and statistical learning tasks	The multivoxel similarity between language processing (or phonological working memory) tasks and the statistical learning task in subject-specific language (or phonological working memory) brain regions.	At the first visit during the school year of the first grade over a two-hour MRI session
Primary	Orthographic statistical sensitivity	The difference in recall accuracy of bigrams/trigrams between the high- vs. low-frequency items in the orthographic serial recall task.	At each of the two measuring time points during the school year of the first grade with three months apart
Primary	Phonological statistical sensitivity	The difference in recall accuracy of bigrams/trigrams between the high- vs. low-frequency items in the phonological serial recall task.	At each of the two measuring time points during the school year of the first grade with three months apart
Secondary	Linguistic SL composite scores	The linguistic SL score will be the average of the letter and the syllable composite scores after averaging across the normalized scores of RT slope, accuracy, and serial recall.	At each of the two measuring time points during the school year of the first grade with three months apart
Secondary	Neural sensitivity to statistical regularities during the statistical learning tasks	The magnitude of BOLD responses to structured vs. random conditions in the syllable and the letter statistical learning tasks.	At the first visit during the school year of the first grade over a two-hour MRI session

External Links

•   PLAUSL Project Website