Clinical Trials Logo
  1. Home
  2. Other
  3. NCT02305134

Tipepidine in Children With Attention Deficit/Hyperactivity Disorder (AD/HD): a Double-blind, Placebo-controlled Trial

Attention Deficit and Disruptive Behavior Disorders Clinical Trial

Official title:
Tipepidine in Children With Attention Deficit/Hyperactivity Disorder (AD/HD): a Double-blind, Placebo-controlled Trial

Clinical Trial Summary

Tipepidine (3-[di-2-thienylmethylene]-1-methylpiperidine) has been used solely as a nonnarcotic antitussive in Japan since 1959. The safety of tipepidine in children and adults has already been established. It is reported that tipepidine inhibits G-protein-coupled inwardly rectifying potassium (GIRK)-channel currents. The inhibition of GIRK channels by tipepidine is expected to modulate the level of monoamines in the brain. We put forward the hypothesis that tipepidine can improve attention deficit/hyperactivity disorder (ADHD) symptoms by modulating monoaminergic neurotransmission through the inhibition of GIRK channels. The purpose of this double-blind, placebo-controlled trial is to confirm whether treatment with tipepidine can improve symptoms in pediatric patients with ADHD.

Clinical Trial Description

Tipepidine (3-[di-2-thienylmethylene]-1-methylpiperidine) has been used solely as a nonnarcotic antitussive in Japan since 1959. The safety of tipepidine in children and adults has already been established. It is reported that tipepidine inhibits G-protein-coupled inwardly rectifying potassium (GIRK)-channel currents. The inhibition of GIRK channels by tipepidine is expected to modulate the level of monoamines in the brain. We put forward the hypothesis that tipepidine can improve attention deficit/hyperactivity disorder (ADHD) symptoms by modulating monoaminergic neurotransmission through the inhibition of GIRK channels. The purpose of this double-blind, placebo-controlled trial is to confirm whether treatment with tipepidine can improve symptoms in pediatric patients with ADHD.

See our previous open trial, An Open Study of Tipepidine Hibenzate in Patients With Attention Deficit Hyperactivity Disorder (ADHD) http://clinicaltrials.gov/show/NCT01835093 ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02305134
Study type Interventional
Source Chiba University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date June 11, 2015
Completion date March 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT00600470 - Effectiveness of Collaborative Services in Primary Care for Treating Children With Behavior Disorders Phase 1/Phase 2
Completed NCT03698240 - Mindfulness-based Program for Children With Disruptive Behavior Disorder N/A
Completed NCT02766101 - Manville Moves: an Exercise Intervention for Behavioral Regulation Among Children With Behavioral Health Challenges N/A
Completed NCT02897570 - Metabolic and Neurofunctional Responses to Breakfasts N/A
Recruiting NCT04946253 - SKIP for PA Study: Team and Leadership Level Implementation Support for Collaborative Care N/A
Completed NCT00402857 - Parent Training to Promote Early Identification and Treatment of Childhood Behavioral Disorders Phase 3
Completed NCT03597789 - Tantrum Tamers 2.0: The Role of Emotion N/A
Recruiting NCT01350986 - Guided Self-Help for Parents of Children With Externalizing Problem Behavior N/A
Completed NCT00163865 - A Pilot Study of Boredom in a Community Sample of Adolescents and a Clinical Sample of Adolescents N/A
Completed NCT02893852 - Effects of CO-OP Approach on Activity and Participation of Brazilian Children With Developmental Coordination Disorder N/A
Terminated NCT02094612 - Effectiveness of the Quotient® ADHD Assessment in a System of Care N/A
Completed NCT01940978 - A Study of Combination Therapy in Children With ADHD Phase 4
Completed NCT03927612 - Virtual Reality to Improve Social Perspective Taking N/A
Completed NCT03976570 - The Effect of Occupational Therapy on Subthreshold Attention Deficit Hyperactivity Disorder N/A
Recruiting NCT04238403 - Peer Professionals to Increase Capacity to Treat ADHD N/A
Completed NCT00218114 - Divalproex Sodium (Depakote) for Explosive Tempers in Adolescents and Adults Phase 3
Completed NCT01919073 - Efficacy of a Brief Behavioral Intervention to Treat ADHD and Disruptive Behaviors In Preschoolers N/A
Completed NCT00236444 - A Study of the Efficacy and Safety of Risperidone in the Prevention of Relapse in Children and Adolescents With Conduct and Other Disruptive Behavior Disorders Phase 3
Completed NCT00001233 - Study of Children at Risk for Disruptive Behavior Disorders N/A
Recruiting NCT05683756 - A Sleep Focused Parenting Intervention for Preschool Aged Children at Risk for ADHD N/A