Atrial Fibrillation Clinical Trial
Official title:
Does Remote Ischemic Preconditioning Reduce the Incidence of Postoperative Atrial Fibrillation in Patient Undergoing Coronary Artery Bypass Graft Surgery?
Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary. Remote ischemic preconditioning (RIPC) is an easy and non-invasive method. Laboratory research has shown promising results regarding myocardial survival during open heart surgery, but the clinical value of RIPC is still largely unknown. The investigators hypothesize that RIPC before coronary artery bypass grafting (CABG) reduces the incidence of postoperative atrial fibrillation (POAF).
Status | Completed |
Enrollment | 92 |
Est. completion date | September 2013 |
Est. primary completion date | January 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Elective isolated on-pump CABG surgery - Informed consent Exclusion Criteria: - Patients with a severe pulmonary disease - Patients with renal failure (GFR<30 mL/min/1.73 m2) - Patients with liver failure - Peripheral vascular disease affecting the upper limbs - Patients on sulfonylurea derivatives. - Patients with atrial fibrillation in their case history - Prior cardiac surgery (Re-operations) |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Norway | St Olavs Hospital Trondheim University Hospital | Trondheim |
Lead Sponsor | Collaborator |
---|---|
Norwegian University of Science and Technology | Helse Møre og Romsdal HF, Levanger Hospital, Namsos Hospital, Sykehuset Innlandet HF |
Norway,
Krogstad LE, Slagsvold KH, Wahba A. Remote ischemic preconditioning and incidence of postoperative atrial fibrillation. Scand Cardiovasc J. 2015 Jun;49(3):117-22. doi: 10.3109/14017431.2015.1010565. Epub 2015 Feb 24. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postoperative atrial fibrillation | A patient will be classified as belonging to the postoperative atrial fibrillation group if they have any episode of atrial fibrillation, measured by telemetry, lasting more than 1 minute during their postoperative days at the hospital. | Up to 10 days after surgery | No |
Secondary | Length of hospital stay | Maximum 14 days | No |
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