Atrial Fibrillation Clinical Trial
Official title:
Assessment of Atrial Tissue Obtained From Patients Undergoing Heart Surgery and Tissue Banking
Verified date | March 2023 |
Source | University of Pittsburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Over the past decade, techniques have been refined which permit an enormous amount of information relevant to disease mechanisms to be gained from the examination of heart tissue. The Cardiovascular Institute has extensive experience with these techniques, and has utilized them to examine other heart disease substrates. In this study, the investigators propose to obtain heart tissue at the time of cardiac surgery which would otherwise be discarded. Their plan is to examine this tissue and correlate their findings with clinical data. Their hope is that the proposed study will provide insight into atrial physiology, including the molecular mechanisms underlying atrial disease and the potential development of atrial fibrillation (AF).
Status | Completed |
Enrollment | 37 |
Est. completion date | February 17, 2016 |
Est. primary completion date | February 17, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - 18 years or over - Referred for heart surgery for standard indication - Competent to give informed consent Exclusion Criteria: - Inability to give informed consent |
Country | Name | City | State |
---|---|---|---|
United States | University Pittsburgh Medical Center | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pittsburgh |
United States,
Li YY, Feldman AM, Sun Y, McTiernan CF. Differential expression of tissue inhibitors of metalloproteinases in the failing human heart. Circulation. 1998 Oct 27;98(17):1728-34. doi: 10.1161/01.cir.98.17.1728. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evidence of atrial physiology | Normally discarded atrial tissue samples will be collected at the time of cardiac surgery and microscopic histology will be performed using standard tissue stains | Visit 1, Atrial tissue sample obtained at the time of surgery | |
Secondary | Evidence of underlying molecular mechanisms of atrial disease | Normally discarded atrial tissue samples will be collected at the time of cardiac surgery and the samples will be assayed for gene expression | Visit 1, Atrial tissue samples obtained at the time of surgery |
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