Atherosclerosis Clinical Trial
Official title:
The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes
The aim of this study is to evaluate whether there is a change in carotid intima media thickness with the application of guide-based exercise programs in individuals with prediabetes, and to evaluate whether there is a difference between the group in which exercise programs were applied and those who received only lifestyle change and metformin.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | March 15, 2023 |
Est. primary completion date | March 15, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Leading a sedentary life - Those who have sufficient motivation to participate in the exercise program (will be evaluated by a one-on-one interview by the researchers) - Have the same weight for 6 months before participating in the study (±2.5 kg) - Those diagnosed with prediabetes by oral glucose tolerance test and/or HbA1c measurement Exclusion Criteria: - Serious medical condition (for example, advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.) that would prevent the person from participating in exercise training. - Having cardiovascular disease - Being diabetic - Using metformin before participating in the study - Receiving hormone replacement therapy - Life expectancy less than 1 year - HIV positivity - Substance use - Functional dependency - Cognitive weakness - Those who have other diseases that will affect the results of the study (respiratory diseases, muscle diseases, etc.) - Those who use drugs or supplements that will affect the results of the study |
Country | Name | City | State |
---|---|---|---|
Turkey | Sultan Abdülhamid Han Training and Research Hospital | Üsküdar | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Carotid ultrasound | milimeter size of carotid intima media thickness | 12 weeks |
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