Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

Atherosclerosis Clinical Trial

Official title:

Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01150019
• Other study ID #: PET_Resistin
• Status: Completed
• Phase: N/A
• First received: June 9, 2010
• Last updated: July 7, 2010
• Start date: April 2010
• Est. completion date: June 2010

Study information

• Verified date: April 2010
• Source: Korea University
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: June 2010
• Est. primary completion date: June 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Healthy volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)

• Diabetes

• Hypertension

• Malignancy

• Severe renal or hepatic disease

• Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Atherosclerosis
• Inflammation

Intervention

Other:
• Cross sectional study
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Locations

Country	Name	City	State
Korea, Republic of	Hae Yoon Choi	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Korea University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET		12 weeks	No
Secondary	Circulating serum adiponectin levels		12 weeks	No
Secondary	carotid intima-media thickness levels measured using ultrasonography		12 weeks	No
Secondary	Circulating serum resistin levels		12 weeks	No