Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

Atherosclerosis Clinical Trial

Official title:

Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation in Healthy Population

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01100671
• Other study ID #: PET_Coronary CT
• Status: Completed
• Phase: N/A
• First received: April 8, 2010
• Last updated: March 12, 2018
• Start date: April 2010
• Est. completion date: August 2011

Study information

• Verified date: March 2018
• Source: Korea University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: August 2011
• Est. primary completion date: July 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

• History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)

• Diabetes

• Stage 2 hypertension (resting blood pressure, = 160/100 mmHg)

• Malignancy

• Severe renal or hepatic disease

• Subjects taking medications that might affect inflammation such as NSIAD and statin

Related Conditions & MeSH terms

• Atherosclerosis
• Inflammation

Intervention

Other:
• Cross section study
This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Locations

Country	Name	City	State
Korea, Republic of	Hye Jin Yoo	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Korea University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation between vascular inflammatory status measured by 18FDG PET and MDCT		20weeks
Secondary	Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT		20 weeks