Correlation Between Various Inflammatory Markers and Vascular Inflammation Measured by 18FDG-PET

Atherosclerosis Clinical Trial

Official title:

Correlation of Inflammatory Markers Such as LpPLA2,MCP-1 and hsCRP for Predicting Vascular Inflammation; Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01022684
• Other study ID #: KOSEF20546
• Status: Completed
• Phase: N/A
• First received: November 27, 2009
• Last updated: February 19, 2010
• Start date: December 2009
• Est. completion date: January 2010

Study information

• Verified date: November 2009
• Source: Korea University
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 150
• Est. completion date: January 2010
• Est. primary completion date: January 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 88 Years

Eligibility

Inclusion Criteria:

• Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

• History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)

• Diabetes

• Stage 2 hypertension (resting blood pressure, =160/100 mmHg)

• Malignancy

• Severe renal or hepatic disease

• Subjects taking medications that might affect inflammation such as NSIAD and statin

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Atherosclerosis
• Inflammation

Intervention

Other:
• Cross section study
This is not intervention study. The purpose of the study is to examine the relationship between various inflammatory markers and PET imaging at the cross section setting

Locations

Country	Name	City	State
Korea, Republic of	Hye Jin Yoo	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Korea University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET		12 weeks	No
Secondary	Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness		12 weeks	No