PET Imaging of Fibroblast Activation in Atherosclerosis

Status Recruiting

Clinical Trial Summary

Fibroblast activation protein (FAP) is a fibroblast-specific marker expressed in atherosclerosis, associated with endothelial-to-mesenchymal transition and a rupture-prone plaque phenotype. This study aims to evaluate in-vivo fibroblast activation in carotid and coronary atherosclerotic diseases with FAPI PET and its correlation with histological vulnerability and clinical outcome.

Clinical Trial Description

Fibroblast activation protein (FAP) is a fibroblast-specific marker expressed in atherosclerosis. Abundant FAP-expressing cells in atherosclerotic plaques co-express endothelial biomarkers involved in endothelial-to-mesenchymal transition. FAP upregulation is also associated with a rupture-prone plaque phenotype with a thin fibrous cap. Positron emission tomography (PET) with 68Ga-FAPI-04 has been demonstrated as a feasible method to image fibroblastic activation in the arterial wall. The current study aims to evaluate in-vivo fibroblast activation in carotid and coronary atherosclerotic diseases with FAPI PET and its correlation with histological vulnerability and clinical outcome. ;

Study Design

Related Conditions & MeSH terms

Atherosclerosis

Clinical Trial Details

NCT number	NCT06280287
Study type	Observational
Source	Peking Union Medical College Hospital
Contact	Li Huo
Phone	+861069155513
Email	huoli@pumch.cn
Status	Recruiting
Phase
Start date	August 1, 2021
Completion date	December 31, 2025

View Details

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