Atherosclerosis Clinical Trial
Official title:
Magnetic Resonance Imaging (MRI) Characterization of Carotid Plaque and Prediction of End-organ and Clinical Outcomes
The Canadian Atherosclerosis Imaging Network (CAIN) is a pan-canadian imaging network funded
through grants from the Canadian Foundation for Innovation (CFI) and the Canadian Institutes
of Health Research (CIHR). This unique research network is focused on the pathobiology of
atherosclerotic disease as it pertains to the coronary and carotid circulations. The CAIN
research program involves the creation of a unique national network focused on in vivo
imaging of vessel wall disease, combined with imaging of occult end-organ disease as well as
the acquisition of clinical and pathological end points. CAIN enables unprecedented
cross-sectional and longitudinal clinical studies of patients with atherosclerotic disease
in coronary or carotid vascular beds, and has established an international resource for
studying the natural history, progression, regression and novel therapeutic interventions
aimed at atherosclerosis.
The primary outcome of this study is to accurately characterise carotid plaque morphology in
non-surgical patients with mild to severe (30-95%) carotid disease. The investigators will
also assess evidence of ischaemic brain disease. Patients will undergo MRI scanning of the
brain and carotid and US scanning of the carotid at baseline and thereafter at 1 and 2 years
or sooner if presenting clinically in order to monitor the natural history of carotid
atherosclerosis and its effect on end-organ brain disease.
Patients will consent to baseline scanning and follow up at 1 and 2 years, and databasing of
clinical and imaging data. After each imaging session images will be processed, stored
locally and also sent to a central repository. 500 patients will be recruited over a 2 year
period in anticipation of study completion within 4 years.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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