The Effect of Vitamin D Administration to Premature Infants on Vitamin D Status and Respiratory Morbidity

Asthma Clinical Trial

Official title: The Effect of Vitamin D Administration to Premature Infants on Vitamin D Status and Respiratory Morbidity During the First Year of Life

Status Completed

Clinical Trial Summary

This trial objective is to assess whether doubling the daily intake of vitamin D improves serum vitamin D levels and serves as primary prevention of respiratory infections and asthma in premature infants.

This is a prospective randomized (1:1) double-blinded trial.

The study population will be randomized into two groups (1:1):

• Intervention Group - 800 IU of Vitamin D once daily

• Control Group - 400 IU of Vitamin D once daily Patients will be followed up for one year after randomization for serum Vitamin D levels and respiratory morbidity.

Clinical Trial Description

The rational of this trial is that a daily supplementation of a double dose of Vitamin D (800 IU instead of 400 IU) to late premature infants during the first year of life will result in elevated Vitamin D serum levels and in an improvement in respiratory morbidity.

This randomized trial of vitamin D supplementation is planned to determine the optimal dose of daily vitamin D supplementation required to achieve sufficient vitamin D levels in preterm infants and to assess whether doubling the daily intake of vitamin D may serve as primary prevention of respiratory infections and asthma in premature infants. ;

Related Conditions & MeSH terms

• Asthma
• Bronchiolitis
• Other Preterm Infants
• Pneumonia
• Vitamin D Deficiency

• NCT number: NCT02404623
• Study type: Interventional
• Source: Soroka University Medical Center
• Status: Completed
• Phase: N/A
• Start date: April 2015
• Completion date: February 12, 2018