Ultrasound in Acute Dyspnea in the Field

Asthma Clinical Trial

Official title:

Combination of Lung Ultrasound(a Comet-tail Sign) and N-terminal Pro-brain Natriuretic Paptide in Differentiating Acute Dyspnea in Prehospital Emergency Setting

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01235182
• Other study ID #: ADMB2010
• Status: Completed
• Phase: N/A
• First received: November 4, 2010
• Last updated: November 4, 2010
• Start date: July 2007
• Est. completion date: August 2010

Study information

• Verified date: July 2007
• Source: University Clinical Centre, Maribor
• Contact: n/a
• Is FDA regulated: No
• Health authority: Slovenia: National Medical Ettics Committee
• Study type: Observational

Clinical Trial Summary

Acute heart failure is one of the main causes of acute respiratory distres in prehospital emergency setting. The early and correct diagnosis is important because the misdiagnosis can result in deleterious consequeance to patients. Rapid bedside tests (like NT-proBNP) and point-of-care lung ultrasound could be useful methods in field. This study confirmed that the combination of ultrasound sign in combination with rapid NT-proBNP test has a hibh diagnostic accuracy in differentiating between cardiac and pulmonray causes of acute dyspnea in the field and the tretament possibilities in clinical obscure cases are mainly improved.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 248
• Est. completion date: August 2010
• Est. primary completion date: April 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Inclusion criterion for the study was shortness of breath as the primary complaint (defined as either the sudden onset of dyspnea without history of chronic dyspnea or an increase in the severity of chronic dyspnea).

Exclusion Criteria:

• Exclusion criteria were age <18 years, history of renal insufficiency, trauma, severe coronary ischemia (unless patient's predominant presentation was dyspnea), and other causes of dyspnea: pneumonia, pulmonary embolism, carcinoma, pneumothorax, pleural effusion, intoxications (drugs), anaphylactic reactions, upper airway obstruction, bronchial stenosis, and gastroesophageal reflux disorder

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Asthma
• COPD
• Heart Failure

Locations

Country	Name	City	State
Slovenia	Center for Emergency Medicine maribor	Maribor

Sponsors (1)

Lead Sponsor	Collaborator
University Clinical Centre, Maribor

Country where clinical trial is conducted

Slovenia, 

References & Publications (1)

Klemen P, Golub M, Grmec S. Combination of quantitative capnometry, N-terminal pro-brain natriuretic peptide, and clinical assessment in differentiating acute heart failure from pulmonary disease as cause of acute dyspnea in pre-hospital emergency setting: study of diagnostic accuracy. Croat Med J. 2009 Apr;50(2):133-42. — View Citation