Asthma Clinical Trial
Official title:
Effect of Allergen Challenge on Inflammation Induced by Toll-like Receptor Stimulation in a Nasal Model.
Asthma is one of the most common diseases affecting about 2.5 million Canadians, and can
result in reduced quality of life and difficulties with work and school. Once the disease
has become established with irreversible changes in the lungs it can be very difficult to
treat. Severe asthma although less common than mild asthma uses more healthcare resources.
The objective of this project is to find out how the changes in the lung develop in severe
asthma. Once this is known then new treatments can be developed to prevent irreversible
damage to the lungs.
Volunteers will have substances sprayed up their nose and then samples collected from their
nose. Levels of proteins and cells can be measured in these samples. This will give an
indication of the type of inflammation that occurs.
The usual method of investigating the changes that occur in asthma is to challenge the
lungs. Samples have to then be collected from the lungs. This can be in the form of sputum
which must be treated to break it down to a liquid or washed out during a camera test. These
methods cause problems with measuring proteins and they are broken down or diluted. Because
the nose is easily accessible samples can be obtained at many time points. Because the
samples can be collected directly from the nose the problems with obtaining samples from the
lung are avoided.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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