Asthma Clinical Trial
Official title:
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma
Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration. This protects healthy subjects against bronchoconstrictive stimuli, and reverses pre-existing bronchoconstriction. However, the deep breath-induced bronchoprotection and -bronchodilation is impaired in asthma. We questioned whether this is specific for asthma (in comparison to COPD), and whether this is associated with bronchial inflammation and -remodelling. The study is a two-groups comparison, of physiological and pathological disease markers, obtained by methacholine challenges, monitoring airways resistance, and by taking bronchial biopsies.
Status | Recruiting |
Enrollment | 36 |
Est. completion date | March 2006 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Asthma according to GINA criteria (www.ginasthma.org) - COPD according to GOLD criteria (www.goldcopd.org) Exclusion Criteria: - nonsmoking - inhaled or oral steroid therapy |
Observational Model: Defined Population, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
Netherlands | Leiden University Medical Center | Leiden |
Lead Sponsor | Collaborator |
---|---|
Leiden University Medical Center | The Netherlands Asthma Foundation |
Netherlands,
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