Asthma Clinical Trial
To identify clinical predictors of episodes of hospital-based care in people with asthma.
BACKGROUND:
This study was of great practical importance because asthma is a common condition (3-5
percent of the population) which has had a recent, unexplained rise in morbidity and
mortality. Many previous epidemiological studies focused on predictors of hospitalization
for people with asthma seen in the emergency room. These studies were of limited value for
the practicing physician who sees the vast majority of patients with asthma.
Results from this study should, for the first time, enable a profile to be constructed of
the high risk patient with asthma which includes identification of modifiable risk factors.
These results can be used for physician and patient education programs as well as to target
medical intervention.
DESIGN NARRATIVE:
The study developed a key piece of information needed for outpatient care of patients with
asthma; a profile of patients at risk for severe, potentially life-threatening exacerbations
of asthma. The experimental design was a prospective study of 800 patients with asthma drawn
from a large, pre-paid health care plan. The key advantage of this population was that all
the care occurred within the health plan. Characteristics identified included demographic
factors, socioeconomic status; patient characteristics such as tobacco use, atopy, pattern
of medication use, self-reporting of compliance/adherence, attitudes about asthma;
historical assessment of indoor air quality; characteristics of asthma such as duration of
asthma, lung function, and variation in asthma symptoms; and speciality of physician. The
outcome measures were obtained over a three year period and included all episodes of
hospital-based care including hospitalizations, emergency room visits, and urgency care
clinic visits. Based on these data, models were developed which assigned relative risk to
each of the independent variables. These models were validated in a subset of the
population.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
Status | Clinical Trial | Phase | |
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Terminated |
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Active, not recruiting |
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Completed |
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Early Phase 1 | |
Recruiting |
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Phase 4 | |
Terminated |
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|
Phase 2 | |
Completed |
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|
N/A | |
Completed |
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|
Phase 2 | |
Completed |
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Phase 2 | |
Completed |
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|
Phase 3 | |
Completed |
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Effect of Inhaled Fluticasone Furoate on Short-term Growth in Paediatric Subjects With Asthma
|
Phase 3 | |
Completed |
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|
Phase 1 | |
Terminated |
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Phase 1 | |
Completed |
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|
Phase 4 | |
Recruiting |
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|
Phase 2 | |
Completed |
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Pharmacodynamics, Safety, Tolerability, and Pharmacokinetics of Two Orally Inhaled Indacaterol Salts in Adult Subjects With Asthma.
|
Phase 2 | |
Completed |
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|
N/A | |
Recruiting |
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||
Withdrawn |
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|
N/A | |
Recruiting |
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|