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Asthma clinical trials

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NCT ID: NCT05935332 Suspended - Asthma Clinical Trials

Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma

Start date: July 5, 2023
Phase: Phase 2
Study type: Interventional

Randomized, multi-center, double-blind, placebo-controlled, parallel group, proof of-concept study with RPT193 in subjects with T2-high, moderate-to-severe asthma who are partially controlled on medium or high doses of inhaled corticosteroids (ICS) in combination with long-acting beta 2 agonist (LABA).

NCT ID: NCT04109807 Suspended - Asthma, Allergic Clinical Trials

Effects of Low Dose Ozone on Airway Inflammatory Responses in Adults With Asthma - Sedentary Nasal Ozone (Asthma SNOZ)

Start date: December 16, 2019
Phase: N/A
Study type: Interventional

To determine if low levels of ozone (O3) encountered on a typical day in Chapel Hill will decrease spirometric values in mild asthmatics.

NCT ID: NCT03467776 Suspended - Asthma Clinical Trials

Bronchial Dilation Test in Wheezy Infants

Start date: July 2018
Phase: N/A
Study type: Observational

The purpose of the study is to establish the methodology of bronchial dilation test by salbutamol MDI with Spacer in wheezy infants with asthma and to evaluate the effects of atopy on the exacerbation of wheeze in wheezy infants.

NCT ID: NCT02853578 Suspended - Asthma Clinical Trials

Busonid® (Budesonide 200 mcg and 400 mcg) to Treat Asthma Not Controlled or Partially Controlled

Laennec
Start date: December 2019
Phase: Phase 3
Study type: Interventional

National clinical trial, phase III, multicenter, single-arm, efficacy study, 80 participants of both sexes, aged equal or more than 12 and less than 65 years. The group will use Busonid® (budesonide 200mcg and 400mcg) one application (inhalation) of 200 mcg every 12 hours (400mcg / day). During follow-up visits if the participant has not shown an increase in forced expiratory volume in one second greater than 12% and greater than 0,20L or 200ml in spirometry compared with baseline visit, will increase the dose to 800 mcg / day (2x 400 mcg day). The study aims to revalidate by the National Health Surveillance Agency (ANVISA) the registration of the drug Busonid® which there is a vast scientific literature on the pre-clinical and clinical evidence that the efficacy and safety of budesonide. Thus, outlined is a single-arm study, which is applied to the study of the group of participants the same intervention for a certain period and the participants are evaluated for response.

NCT ID: NCT02140684 Suspended - Asthma Clinical Trials

Exhaled Nitric Oxide in Asthma Management

Start date: March 2012
Phase: N/A
Study type: Observational

This study will compare the absolute and relative effectiveness of managing real-life asthma with and without the use of NIOX MINO® and NIOX Flex® to measure exhaled nitric oxide (eNO) as a marker of underlying airway inflammation to guide appropriate management. As exhaled nitric oxide responds rapidly to environmental changes and can act as a marker of underlying inflammation it is proposed that incorporating eNO monitoring into routine asthma management treatment allows strategies to be more accurately tailored to the patients needs, increasing the probability of good asthma control.

NCT ID: NCT02047370 Suspended - Asthma Clinical Trials

Manual Therapy in Patients With Asthma

Start date: January 2014
Phase: N/A
Study type: Interventional

Physical therapists have traditionally included various forms of manual therapy among the therapeutic approaches to respiratory conditions. The aim of this study was to evaluate the effect of diaphragmatic stretching technique on pulmonary ventilation, rig bage excursion and spirometric values in patients diagnosed with asthma.

NCT ID: NCT01508078 Suspended - Asthma Clinical Trials

Characterization of Adult Subjects for Asthmatic Research Studies

CASA
Start date: May 2010
Phase:
Study type: Observational

This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained in all subjects. These include a medical history and baseline lung function tests. This characterization forms the basis for our database that facilitates research protocols.

NCT ID: NCT01345396 Suspended - Asthma Clinical Trials

Influence of an Asthma Education Programme on Asthma Control During Pregnancy

Start date: February 2010
Phase: N/A
Study type: Interventional

Asthma is the most frequent respiratory disease during pregnancy. In a third of cases, the level of asthma control can decrease during the pregnancy, especially between the 29th and the 36th week. The occurrence of such complications are linked with a high asthma severity level just before the conception and an history of respiratory complications in a previous pregnancy. Many reviews and recommendations claim that pregnant women with asthma should be included in an educational progamme. However, this is poorly studied. The purpose of this study is to observe if an educational programme given before the 20th weeks of gestation has an effect on asthma control until the end of gestation.

NCT ID: NCT00967967 Suspended - Asthma Clinical Trials

Validation of the Rhinitis Control Scoring System (RCSS)

RCSS
Start date: March 2009
Phase: N/A
Study type: Interventional

Many patients suffering from allergic rhinitis do not recognize or perceive their symptoms. Instruments have been developed to assess quality of life in rhinitis, asthma or both, but there is a need to develop validated tools or methods to assess rhinitis control among rhinitis and/or asthmatic patients. The aim of this study is to assess the discriminative and evaluative properties of the RCSS in asthmatic patients with allergic rhinitis.

NCT ID: NCT00594750 Suspended - Asthma Clinical Trials

Mechanisms of Exacerbation of Asthma

MECA
Start date: May 2006
Phase:
Study type: Observational

The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.