Asthma in Overweight Adults Clinical Trial
Official title:
Effects of Aerobic Exercise on Asthmatic Responses in Obese Adults
This pilot study will use an unmasked, parallel group, randomized design. Thirty adult overweight or obese subjects with mild-moderate persistent asthma will be randomly assigned to one of two groups: 12-weeks of home-based moderate intensity aerobic exercise versus no intervention. The study will include 2 clinic visits and 12 telephone calls. Exercise testing to assess physical fitness levels will occur during visits 1 and 2. Blood sampling for biomarkers, inflammatory markers, and other assessments will be done.
The primary aim of this pilot study is to recruit and retain obese adults with mild-moderate
persistent asthma for a study protocol that includes exercise at a moderate intensity level
in a home-based setting. The investigators primary hypothesis is that compared to no
intervention, 12-weeks of moderate intensity aerobic exercise will attenuate serum levels of
adipokines (leptin, adiponectin), and other pro-inflammatory markers. The investigators will
also analyze the effect of the intervention on fitness levels, pulmonary function, asthma
symptoms, asthma control, and asthma-related quality of life.
Given that this is a proof of concept/feasibility study, there is no primary outcome measure.
The following measures will be assessed:
- Obesity related biomarkers and other markers of inflammatory responses:
- Asthma symptoms and asthma control measures:
- Lung function
- Fitness levels and physical activity levels:
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