Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma

Asthma, Allergic Clinical Trial

Official title:

A Phase 2 Multi-centre Randomized Double-blind Placebo-controlled Parallel Group Study to Examine the Effects of 24 Weeks Tezepelumab 210 mg sc q4wks on Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05740748
• Other study ID #: ESR-22-21828
• Status: Not yet recruiting
• Phase: Phase 2
• Start date: April 1, 2023
• Est. completion date: December 30, 2024

Study information

• Verified date: February 2023
• Source: McMaster University
• Contact: Gail M Gauvreau, PhD
• Phone: 9055259140
• Email: gauvreau[@]mcmaster.ca
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze. Mast cells are immune cells in airways that can release chemical causing constriction of the airways and wheeze. Tezepelumab is an injectable medication that improves asthma by stopping inflammation, but the effect on mast cells is not known. Tezepelumab was approved in Canada July 2022 for treatment of severe asthma. Tezepelumab is not approved for treatment of mild asthma by any health authority, except for use in research studies like this. This study will examine the effect of tezepelumab on mast cells and airway constriction to understand the mechanisms of asthma, and which patients will benefit most from drugs like tezepelumab.

Description:

The proposed study will address whether tezepelumab has the unique ability to improve AHR in participants with mild allergic asthma.

This is a phase 2 multi-centre randomized double-blind placebo-controlled parallel-group study to examine the effects of 24 weeks tezepelumab 210 mg sc q4wks on methacholine airway hyperresponsiveness in participants with mild allergic asthma, stratified for sex and sensitivity to seasonal allergens.

There are 9 study visits over a period of 27 weeks (Figure 1). Study procedures performed at Weeks -1, 8, 16 and 24 will be divided across 2 visits at least 48 hours apart for measurement of AHR to methacholine first, and mannitol at least 48 hours later.

The screening period at Week -1 will determine eligibility. At Week -1, eligible allergic mild asthmatic participants will be randomized 1:1 to placebo or tezepelumab 210 mg subcutaneous administered monthly for a total of 24 weeks. AHR will be measured by methacholine and mannitol challenges at baseline (Week -1) performed at least 48 hours apart. Changes in AHR response will be measured by repeat methacholine and mannitol challenges at Weeks 8, 16 and 24.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 34
• Est. completion date: December 30, 2024
• Est. primary completion date: December 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Provision of informed consent prior to any study specific procedures

2. Male and female 18 through 65 years of age

3. Positive skin-prick test to a common aeroallergen

4. Methacholine PD20 = 200mcg

5. Mannitol DRR = 42.3mg/FEV1 %f all (equivalent to PD15 = 635mg)

6. Baseline FEV1 = 70% of the predicted value

7. Negative pregnancy test (urine) for female participants of childbearing potential.

Exclusion Criteria:

1. Current or former smoker with >10-pack-year history

2. Current or previous history of lung disease other than mild stable allergic asthma

3. Significant systemic disease, including history of current malignancy or autoimmune disease

4. Involvement in the planning and/or conduct of the study (applies to both Investigator staff and/or staff at the study site)

5. Previous randomisation in the present study. Re-screening (Week -1) for FEV1 and AHR is permitted once for each test.

6. Participation in another clinical study with an investigational product during the last 30 days or 5 half-lives of the drug (whichever is longer)

7. Use of any medications for treatment of asthma other than prophylactic short-acting ß2-agonists, or use of short-acting ß2-agonists for relief of symptoms less than once weekly.

8. Participants with known hypersensitivity to tezepelumab or any of the excipients of the product.

9. Positive hepatitis C antibody, hepatitis B virus surface antigen or hepatitis B virus core antibody, at screening

10. Known to have tested positive for human immunodeficiency virus

11. Known history of drug or alcohol abuse within 1 year of screening

12. For women only - currently pregnant (confirmed with positive pregnancy test) or breast feeding.

13. Unwillingness or inability to comply with the study protocol for any other reason.

Related Conditions & MeSH terms

• Asthma
• Asthma, Allergic
• Respiratory Hypersensitivity

Intervention

Drug:
• Tezepelumab
tezepelumab 210 mg sc q4wks for 20 weeks
• Placebo
placebo sc q4wks for 20 weeks

Locations

Country	Name	City	State
Canada	McMaster University	Hamilton	Ontario
Canada	University of Saskatchewan	Saskatoon	Saskatchewan

Sponsors (2)

Lead Sponsor	Collaborator
McMaster University	University of Saskatchewan

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Methacholine PD20	The provocative dose of methacholine causing 20% fall in FEV1	Week -1 to Week 24
Secondary	Dose response ratio to mannitol	The mannitol dose response ratio calculated by dividing the total cumulative dose by the % fall in FEV1 at that dose.	Week -1 to Week 24
Secondary	Mast cell tryptase levels.	Level of mast cell-derived tryptase in blood and urine at Week 24.	Week -1 to Week 24