Dupilumab Effects Against Aeroallergen Challenge

Status Recruiting

Clinical Trial Summary

The trial involves two interventions: (i) exposure to HDM in the ACC and (ii) administration of dupilumab/placebo for dupilumab.

Clinical Trial Description

(i)Intervention #1: HDM exposures in the ACC This trial utilizes exposures to House dust mites (HDM) in the Aeroallergen Challenge Chamber (ACC) as a two-pronged tool for (i) precision phenotyping of HDM+PARC+AA+ persons to identify those with the adaptive and maladaptive phenotypes and (ii) assessment of symptoms intermittently throughout the clinical trial to monitor effects of dupilumab/placebo on symptom severity . (ii) Participants classifying to the adaptive and maladaptive phenotypes are then randomized to 18-weeks dupilumab vs. placebo, with ACC HDM visits during this phase. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05720325
Study type	Interventional
Source	The University of Texas Health Science Center at San Antonio
Contact	Sunil K Ahuja, MD
Phone	210-567-4823
Email	ahujas@uthscsa.edu
Status	Recruiting
Phase	Phase 2
Start date	March 29, 2023
Completion date	November 2027

View Details

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