Asthma, Allergic Clinical Trial
Official title:
Mechanistic Trial of Dupilumab in Adults With House Dust Mite-associated Asthma Using an Aeroallergen Challenge Chamber
The trial involves two interventions: (i) exposure to HDM in the ACC and (ii) administration of dupilumab/placebo for dupilumab.
(i)Intervention #1: HDM exposures in the ACC This trial utilizes exposures to House dust mites (HDM) in the Aeroallergen Challenge Chamber (ACC) as a two-pronged tool for (i) precision phenotyping of HDM+PARC+AA+ persons to identify those with the adaptive and maladaptive phenotypes and (ii) assessment of symptoms intermittently throughout the clinical trial to monitor effects of dupilumab/placebo on symptom severity . (ii) Participants classifying to the adaptive and maladaptive phenotypes are then randomized to 18-weeks dupilumab vs. placebo, with ACC HDM visits during this phase. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04435990 -
Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites
|
Phase 3 | |
Completed |
NCT03563521 -
Identifying Serum Cytokine Profiles of Distinct Inflammatory Phenotypes in Severe Asthma
|
||
Completed |
NCT02990117 -
ICS Treatment Compliance of Asthma Patients
|
||
Completed |
NCT03468790 -
Anti-IgE Monoclonal Antibody Treatment in Patients With Allergic Asthma.
|
Phase 3 | |
Recruiting |
NCT04898283 -
Efficacy and Safety Evaluation of the Treatment of Allergy Against Cupressaceae and Grasses.
|
Phase 3 | |
Recruiting |
NCT03455959 -
Lung-Resident Memory Th2 Cells in Asthma
|
N/A | |
Not yet recruiting |
NCT05352126 -
Effects of Puressentiel Purifying Spray on Asthma Control in Patients With Mild to Moderate Allergy-induced Asthma.
|
N/A | |
Completed |
NCT01104012 -
Validation of Proteomic Analyses for Allergic Asthma and Rhinitis
|
N/A | |
Not yet recruiting |
NCT06027073 -
Biologics and Sublingual Immunotherapy
|
Phase 4 | |
Completed |
NCT03112577 -
Study of REGN3500 and Dupilumab in Patients With Asthma
|
Phase 1 | |
Recruiting |
NCT04891237 -
Efficacy and Safety Evaluation for the Treatment of Allergy Against Grass and Olive Pollen
|
Phase 3 | |
Terminated |
NCT02953106 -
Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis
|
Phase 4 | |
Completed |
NCT06063044 -
Food-specific IgG4-guided Elimination Diets Improve Allergy Symptoms in Children
|
||
Completed |
NCT03705325 -
Evaluating Asthma Exacerbation-induced Changes in Lung Function With a Home-based Spirometer
|
N/A | |
Recruiting |
NCT05478824 -
IL13 Signaling in Allergic Asthma
|
||
Suspended |
NCT04109807 -
Effects of Low Dose Ozone on Airway Inflammatory Responses in Adults With Asthma - Sedentary Nasal Ozone (Asthma SNOZ)
|
N/A | |
Withdrawn |
NCT04035109 -
Anakinra as a Rescue Treatment for Allergic Inflammation
|
Phase 1/Phase 2 | |
Recruiting |
NCT03983603 -
Plant Stanol Esters and Preventing Asthma Symptoms
|
N/A | |
Not yet recruiting |
NCT05740748 -
Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma
|
Phase 2 |