Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

Appetite Clinical Trial

Official title:

Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02666586
• Other study ID #: B2015:110
• Status: Completed
• Phase: N/A
• Start date: January 2016
• Est. completion date: October 21, 2017

Study information

• Verified date: April 2021
• Source: University of Manitoba
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To describe the effect and mechanisms of action faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years).

Description:

The overall objective is to describe the effect and mechanisms of action of faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years). The specific objectives are to test the acute effects of different faba bean ingredient smoothie on: 1) post-prandial blood glucose, appetite, satiety hormone and insulin for 200 minutes, and 2) food intake 120 minutes following consumption of the faba bean smoothie. Two short-term acute studies will be conducted to meet these objectives. Both acute studies will follow a randomized, double blinded, balanced, repeated measures design and the same protocol; except one will have an ad libitum pizza meal (study 1), while the other will have a fixed pizza meal (study 2) at 120 minutes. Half the participants will have blood drawn by IV and the other half will be finger prick.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: October 21, 2017
• Est. primary completion date: October 21, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy

• non-smoking males

• aged 20-30 years (min/max age)

• a body mass index between 20 and 25 kg/m2 (the range generally accepted as ideal/healthy by Health and Welfare Canada)

Exclusion Criteria:

• individuals diagnosed with diabetes

• those on medication

• breakfast skippers

• on an energy restricted diet

• this study excludes females because appetite and blood glucose during the female menstruation cycle changes due to fluctuations in hormones

Related Conditions & MeSH terms

• Appetite
• Faba Bean
• Insulin
• Post-prandial Blood Glucose
• Satiety Hormones

Intervention

Other:
• Faba bean powder smoothie
Breakfast smoothie with 32 g whole faba bean powder (300g).
• Faba bean protein concentrate smoothie
Breakfast smoothie with 32 g faba bean protein concentrate.
• Faba bean starch smoothie
Breakfast smoothie with 33 g faba bean starch.
• Faba bean protein isolate smoothie
Breakfast smoothie with 32 g faba bean protein isolate.
• Non-pulse smoothie smoothie
Control smoothie with 32 g corn maltodextrin without added faba bean fractions.

Locations

Country	Name	City	State
Canada	Richardson Centre for Functional Foods and Nutraceuticals	Winnipeg	Manitoba

Sponsors (1)

Lead Sponsor	Collaborator
University of Manitoba

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	blood glucose	measured by finger prick blood samples by glucose meters	0-200 minutes
Secondary	appetite	measured by VAS questionnaire	0-200 minutes
Secondary	satiety hormones	measured by enzyme-linked immunosorbent assay (ELISA)	0- 200mins
Secondary	insulin	measured by ELISA	0-200mins
Secondary	food intake	energy intake at ad-libitum pizza meal	120 minutes following consumption of the faba bean smoothie
Secondary	physical comfort	measured by VAS questionnaire	0-200 minutes
Secondary	energy/fatigue	measured by VAS questionaire	0-200 minutes