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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02053025
Other study ID # CRO1332
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 2010
Est. completion date October 2012

Study information

Verified date October 2019
Source Imperial College London
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to investigate the effect of eating various levels of mycoprotein (Quorn) on feelings of appetite, energy intake and levels of gut hormones in overweight volunteers.


Description:

Owing to its relatively high protein and fibre content, mycoprotein presents an attractive food product to improve appetite regulation and postprandial glycaemic and insulin responses in overweight and obese individuals at risk of developing T2DM


Recruitment information / eligibility

Status Completed
Enrollment 52
Est. completion date October 2012
Est. primary completion date October 2012
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Males and females between the ages of 18 and 65

- body mass index (BMI) 25-32kg/m2

- Weight stable over the past 6 months

- No known major illness or eating disorder nor on any medication that may impact on appetite or hormone levels.

- No paracetamol or other analgesic in the previous 48 hours

- A score of <2.5 in the Dutch Eating Behaviour Questionnaire (DEBQ)

- A score of <2 in the SCOFF questionnaire

Exclusion Criteria:

- Persons outside the age and BMI ranges stated above

- Pregnant and lactating women

- Weight variation of greater than 5% in the last 6 months

- Any diagnosed major illness

- Any paracetamol or analgesic intake in the last 48 hours

- Diagnosed eating disorder

- Allergy to mycoprotein or mushrooms

- Regular consumption of Quorn products

- Dislike of any of the test foods or drinks

- A score of >2.5 in the Dutch Eating Behaviour questionnaire

- A score of 2 or more in the SCOFF questionaire

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
mycoprotein

control protein


Locations

Country Name City State
United Kingdom Imperial College NIHR CRF London

Sponsors (1)

Lead Sponsor Collaborator
Imperial College London

Country where clinical trial is conducted

United Kingdom, 

References & Publications (1)

Bottin JH, Swann JR, Cropp E, Chambers ES, Ford HE, Ghatei MA, Frost GS. Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obe — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Energy intake at ad-libitum meal Energy intake will be assessed during an ad-libitum meal at 180 minutes at the end of each study visit. Participants will be offered a meal in excess and asked to eat until they feel comfortably full. The meal will be weighed before and after consumption and energy intake will be calculated from the manufacturer's reported nutritional composition. upon completion of all participants, expected timeframe: 2 years
Secondary Glucagon-like peptide-1 (GLP-1) Plasma glucagon-like peptide-1 (GLP-1) concentrations will be measured by radioimmunoassay (RIA) at the end of the study upon completion of all participants, expected at 2 years
Secondary peptide tyrosine-tyrosine (PYY) levels Plasma peptide tyrosine-tyrosine (PYY) concentrations will be measured by radioimmunoassay (RIA) at the end of the study upon completion of all participants, expected at 2 years
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