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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT04158232
Other study ID # 306
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date November 2, 2019
Est. completion date November 2, 2020

Study information

Verified date November 2019
Source Minia University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 20
Est. completion date November 2, 2020
Est. primary completion date September 2, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 11 Years to 50 Years
Eligibility Inclusion Criteria:

- Patients with mature teeth.

- Patients with periapical periodontitis.

- Maxillary anterior teeth only will be involved.

- Patients should be free from any systemic disease that may affect normal healing and predictable outcome.

- Patients who will agree to the consent and will commit to follow up period.

Exclusion Criteria:

- Patients with immature roots.

- Patients with any systemic disease that may affect normal healing.

- Patients with swelling.

- Pregnant females.

- Patients who could/would not participate in a 1 year follow up.

- Patients with fistula.

- Patients with old age.

- Teeth with periodontal involvement.

- Teeth with vertical root fractures.

- Unrestorable teeth.

Study Design


Intervention

Other:
Method
treatment of mature teeth with apical periodontitis

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Minia University

Outcome

Type Measure Description Time frame Safety issue
Primary clinical success pulp vitality testing using electric pulp tester which detect response of pulp to electric current 9 months
Primary radiographic success healing of apical periodontitis by detecting change in apical radiolucency and absences of apical bone resorption 9 months
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