Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Apical Periodontitis Clinical Trial

Official title:

Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04158232
• Other study ID #: 306
• Status: Not yet recruiting
• Phase: N/A
• Start date: November 2, 2019
• Est. completion date: November 2, 2020

Study information

• Verified date: November 2019
• Source: Minia University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 20
• Est. completion date: November 2, 2020
• Est. primary completion date: September 2, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 11 Years to 50 Years

Eligibility

Inclusion Criteria:

• Patients with mature teeth.

• Patients with periapical periodontitis.

• Maxillary anterior teeth only will be involved.

• Patients should be free from any systemic disease that may affect normal healing and predictable outcome.

• Patients who will agree to the consent and will commit to follow up period.

Exclusion Criteria:

• Patients with immature roots.

• Patients with any systemic disease that may affect normal healing.

• Patients with swelling.

• Pregnant females.

• Patients who could/would not participate in a 1 year follow up.

• Patients with fistula.

• Patients with old age.

• Teeth with periodontal involvement.

• Teeth with vertical root fractures.

• Unrestorable teeth.

Related Conditions & MeSH terms

• Apical Periodontitis
• Dental Pulp Necrosis
• Periapical Periodontitis
• Periodontitis

Intervention

Other:
• Method
treatment of mature teeth with apical periodontitis

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Minia University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	clinical success	pulp vitality testing using electric pulp tester which detect response of pulp to electric current	9 months
Primary	radiographic success	healing of apical periodontitis by detecting change in apical radiolucency and absences of apical bone resorption	9 months