Outcomes of Type A Aortic Dissection Repair — STAAD  

Aortic Valve Insufficiency Clinical Trial

Official title: Surgical Strategy for Repair of Type A Aortic Dissection: A Multicenter Registry

Status Enrolling by invitation

Clinical Trial Summary

Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity. In acute forms of type A aortic dissection (TAAD) mortality is 50% by 24 h and 50% of patients die before reaching a specialist center. Rapid diagnosis and subsequent prompt surgical repair remain the primary goal for these patients. In the last decade it has been observed that improvements in diagnostic techniques, initial management and increased clinical awareness have contributed to a substantial increase in the number of patients benefiting from a prompt diagnosis and undergoing surgery.However, survival after surgical repair has not yet reached optimal follow-ups and is burdened by high in-hospital mortality(16-18%)

Clinical Trial Description

For patients requiring surgical repair for a TAAD, there is still some disagreement regarding which factors should be considered during the preoperative evaluation, the best decision-making process to undertake that best assesses procedural risk, and how operative mortality can be predicted. Furthermore, the impact of different surgical strategies on outcomes remains unclear.This prospective study was designed to evaluate the impact of the center volume-outcome relationship and that on mortality which remain poorly understood. A better understanding of the determinants of outcome in patients undergoing surgery could support decision making, aid in the design of service delivery, and improve outcomes for surviving patients who are referred to specialized centers for treatment of aortic disease.Furthermore, the study aims to evaluate whether precise risk stratification can provide better patient counseling and be used for unit-surgeon benchmarking. Ultimately in the present study, we aimed to investigate outcome predictors in patients undergoing surgery for TAAD, including clinical and perioperative variables as well as to evaluate follow up beyond 15 years. ;

Related Conditions & MeSH terms

• Aortic Arch
• Aortic Diseases
• Aortic Dissection
• Aortic Root Dilatation
• Aortic Root Dissection
• Aortic Valve Insufficiency
• Ascending Aortic Dissection
• Type A Aortic Dissection

• NCT number: NCT05927090
• Study type: Observational [Patient Registry]
• Source: Centre Cardiologique du Nord
• Status: Enrolling by invitation
• Start date: January 1, 2005
• Completion date: December 30, 2024