Clinical Trials Logo
  1. Home
  2. Aortic Aneurysm, Abdominal
  3. NCT02995642

Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation

Aortic Aneurysm, Abdominal Clinical Trial

Official title:
Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation

Clinical Trial Summary

Stroke and abdominal aortic aneurysms (AAAs) are common and highly lethal vascular diseases. Angiogenesis and infiltration of inflammatory cells such as macrophages may cause stroke and AAAs. The purpose of this study is to test PET/CT and PET/MRI imaging to specifically detect those diseases using a new developed agent (18F-FPPRGD2) that can target angiogenesis and macrophages.

Clinical Trial Description

20 subjects with either carotid bifurcation stenosis of >50% by ultrasound on at least one side (10 patients) or advanced AAAs (10 patients) and surgical intervention planned will be identified from physicians from the Division of Vascular Surgery at Stanford. Either a PET/CT or a PET/MRI will be performed for each subject: - PET/CT scans will be performed in 3D mode using GE Discovery 600 or GE Discovery 690 scanners (GE Healthcare). - PET/MRI scans will be performed using the novel PET/MRI system at Stanford, including a sensitive PET time-of-flight (TOF) scanner with an advanced 3T MRI scanner. The study patients will receive an intravenous administration of 10mCi of the prescribed radiotracer (18F-FPPRGD2). PET/CT or PET/MRI images will be obtained starting 45-60 minutes after radiotracer administration. For PET/CT, each image acquisition will begin with a non-contrast CT scan obtained from the vertex through the mid-thighs of the subjects. For PET/MRI, non-contrast images of the carotid or aorta will be performed. PET imaging will follow. Patient's vital signs will be monitored during the procedure and a physician will be available if there is need for immediate medical attention. The PET images will be reconstructed with a standard iterative algorithm using GE software release 5.0. After the planned surgery, we will also assess the histopathological correlation between the disease lesions and PET/CT or PET/MRI imaging characteristics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02995642
Study type Interventional
Source Stanford University
Contact
Status Withdrawn
Phase Phase 2
Start date October 2019
Completion date December 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT03657979 - TAP-Block in Abdominal Aortic Surgery Phase 4
Enrolling by invitation NCT01465425 - Extracolonic Findings on Computed Tomography (CT) Colonography
Completed NCT02845167 - Effect of Preoperative Exercise on Postoperative Outcome in AAA Patients: Pilot Study N/A
Not yet recruiting NCT00358085 - NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Phase 3
Terminated NCT00118573 - Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Phase 4
Completed NCT04792411 - Adherence and Acceptability of a Remote, Home-based, Pre-surgery Programme for Patients Undergoing Abdominal Aortic Aneurysm Surgery N/A
Completed NCT04930172 - TOtal tRansfemoral branCHed endovasCular tHoracoabdominal Aortic Repair Registry
Completed NCT01980901 - Post-Approval Study of the Ovation™/Ovation Prime™ Abdominal Stent Graft System
Active, not recruiting NCT01698671 - InterGard Synergy Post-Marketing Surveillance Study N/A
Enrolling by invitation NCT00831870 - EndoSure Sensor for Long-term Follow-up After Endovascular AAA Repair N/A
Recruiting NCT05972018 - Liposomal Bupivacaine/Bupivacaine in RS Blocks vs. Ropivacaine in RS Blocks And Catheters Phase 4
Not yet recruiting NCT02997618 - The AAA Get Fit Trial: A Pilot Randomised Controlled Trial of Community Based Exercise in Patients With Abdominal Aortic Aneurysms N/A
Active, not recruiting NCT02907762 - Aorfix Intelliflex First in Human Study
Completed NCT00349947 - Exercise Therapy to Treat Adults With Abdominal Aortic Aneurysms Phase 1
Completed NCT04080557 - Abdominal Aortic Aneurysm Patients Remain at Risk for Delirium on the Surgical Ward After Intensive Care Unit Dismissal
Recruiting NCT05484115 - Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck N/A
Recruiting NCT04503395 - ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES N/A
Completed NCT02867501 - Venous Distension in Patients With Aneurysmatic Arterial Disease N/A
Recruiting NCT02345590 - Eplerenone in the Management of Abdominal Aortic Aneurysms Phase 4
Recruiting NCT01985906 - Safety and Efficacy of Multiple Overlapping Uncovered Stents for Pararenal Aortic Aneurysm Repair N/A