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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04394039
Other study ID # NUS-IRB_S-20-12
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date June 1, 2020
Est. completion date December 31, 2020

Study information

Verified date July 2021
Source National University, Singapore
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In this study it is aimed to investigate the difference between the brain response to different urban environments in Singapore before and after the COVID-19 pandemic. The datasets acquired from 34 healthy individuals as part of ongoing study "Effects of Landscape on the Brain" (IRB Ref #: S-18-352) will be used. These datasets consist of neurophysiological data recordings and behavioral self-reported measures and were collected before 20 of January 2020. The same experimental protocol would be followed, given that the data collection in the lab-setting would start after 7 th May 2020/whenever research activities are allowed to resume, and the outdoor sessions after the "circuit-breaker" period in Singapore is over.


Description:

The aim is to explore the difference between pre and post COVID-19-related isolation on their perception of green and public spaces, as well as mood, neuroelectrical (EEG) and haemodynamic (fNIRS) response. The hypothesi is that crowded, busy public spaces, such as experimental site near Chinatown MRT, may induce more patterns of brain activity related to stress, anxiety and aversive attitudes after COVID-19 as compared to before. Similarily, it is expected that green urban spaces, such as experimental site at Hortpark, perceived after COVID-19 can elicit more salutogenic effect of relaxation, positive emotions and attention restoration than before the pandemic. This study will allow better understanding of the mental health consequences of unprecedented period of isolation at home and social distancing. The relationship between city residents and their living environment may change due to COVID-19 and it's very important to uncover the mental health implications of social distancing to prepare for potential future outbreaks through developing tools and solutions addressing specific issues. Finally, for the urban planning and design the study may highlight important trends in changing human perception of space and redefine the concept of a "healthy city".


Recruitment information / eligibility

Status Completed
Enrollment 34
Est. completion date December 31, 2020
Est. primary completion date August 1, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 21 Years to 75 Years
Eligibility Inclusion Criteria: - Age of 21 to 75 - Right-handed only Exclusion Criteria: - left-handed - serious visual or auditory impairment - Major neurological disorders e.g. epilepsy, stroke - Any form of cancer - Major heart diseases: e.g. ischemic heart disease - Major lung diseases: e.g. chronic obstructive pulmonary disorder. - Major liver disease e.g. liver failure - Major kidney disease e.g. kidney failure

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Public space exposure
landscapes with nature and/or classified as contemplative (through a CLM psychometric measure) are expected to elicit different brainwave oscillations as compared to noncontemplative ones.

Locations

Country Name City State
Singapore Institute for Health Innovation & Technology (iHealthtech) Singapore

Sponsors (2)

Lead Sponsor Collaborator
National University, Singapore National University Hospital, Singapore

Country where clinical trial is conducted

Singapore, 

Outcome

Type Measure Description Time frame Safety issue
Primary EEG power in alpha band predictor of positive affect and positive mental health outcomes, measured with EEG 5 minutes
Primary EEG power in beta band more beta in the right temporal lobes associated with stimuli-driven attention, measured with EEG 5 minutes
Primary fNIRS haemodynamics decreased oxy-hemoglobin in the frontal part of the brain indicates more relaxation 5 minutes
Secondary Profile of mood states self-reported, pre-and post- stimulation Profile of Mood States (POMS) scale measures the change in the momentary mood, giving as an outcome measure the Total Mood Disturbance (TMD), where 1 is neutral, and above 1 is disturbed mood 30 minutes
Secondary landscape preference measured with self-assessment manikin scale measured using pictorial Self-Asessment Manikin (SAM) where score ranged from -3 to +3, where the lower the score the less positive (valence + arousal) emotions are caused by looking at the view 30 minutes
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