Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics

Status Completed

Clinical Trial Summary

This is an observational study to assess the change in several psychological screening tools before and after a series of six ketamine infusions in paramedics who suffer from post traumatic stress disorder as a result of working in emergency medical services.

Clinical Trial Description

Working as a paramedic in a prehospital emergency medical services system (EMS) has been shown to lead to increased incidence of post traumatic stress disorder (PTSD) and increased risk of suicide in prehospital personnel. In recent years a growing body of literature has shown that ketamine hydrochloride can be an effective treatment for PTSD. This study seeks to look specifically at paramedic level emergency medical technicians ("paramedics") with PTSD related to their prehospital work and assess whether ketamine infusion therapy can be an effective treatment for them. This is an observational study where the results of psychological screening tools that are administered before and after a six-infusion series are reported. Additionally the same assessment tools will be administered again 30 days after the final treatment to measure the durability of any changes. The participants will receive the Periodic Health Questionnaire-9 (PHQ-9), the PTSD Checklist for Diagnostic and Statistical Manual, DSM-5 (PCL-5), the Alcohol Use Disorders Identification Test (AUDIT), and the Beck Anxiety Inventory (BAI) before the infusions, after the series of six, and thirty days later. Additionally, after the series of six infusions, participants will receive the Revised Mystical Experience Questionnaire-30 (RMEQ-30) and a one question survey to assess the impact of the experiential aspect of ketamine. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03947099
Study type	Observational
Source	Klarisana Physician Services PLLC
Contact
Status	Completed
Phase
Start date	May 2, 2019
Completion date	February 22, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03535805` - Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances	N/A
Active, not recruiting	`NCT05006976` - A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study	N/A
Recruiting	`NCT05419934` - EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial	N/A
Active, not recruiting	`NCT04136054` - Better Sleep in Psychiatric Care - Anxiety and Affective Disorders	N/A
Completed	`NCT04091139` - Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong	Phase 2/Phase 3
Completed	`NCT04647318` - Physiological Response to Self-compassion Versus Relaxation	N/A
Active, not recruiting	`NCT05114824` - Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students	N/A
Recruiting	`NCT05843695` - Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety	N/A
Completed	`NCT05078450` - Mood Lifters Online for Graduate Students and Young Professionals	N/A
Not yet recruiting	`NCT06162624` - Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons	N/A
Not yet recruiting	`NCT05747131` - Emotion Detectives In-Out: Feasibility and Efficacy of a Blended Version of the Unified Protocol for Children	N/A
Not yet recruiting	`NCT05863637` - Intensive Short-Term Dynamic Psychotherapy (ISTDP) for Anxiety Diagnoses in a Primary Care Setting	N/A
Not yet recruiting	`NCT05225701` - Efficacy of a Transdiagnostic Guided Internet-Delivered Intervention for Emotional, Trauma and Stress-Related Disorders.	N/A
Completed	`NCT02579915` - Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC)	N/A
Recruiting	`NCT02376959` - Effect of Spiritist "Passe" Energy Therapy in Reducing Anxiety in Volunteers	N/A
Recruiting	`NCT02186366` - Efficacy Study of Abdominal Massage Therapy to Treat Generalized Anxiety Disorder of Deficiency of Both Heart and Spleen Type	N/A
Not yet recruiting	`NCT02126787` - Short-term, Intensive Psychodynamic Group Therapy Versus Cognitive-behavioral Group Therapy in the Day Treatment	N/A
Withdrawn	`NCT01953042` - Benefits of a Psychoeducation Program for Those Awaiting Treatment for OCD and OCD Spectrum Disorders	N/A
Completed	`NCT02134730` - School-based Universal Prevention for Anxiety and Depression in Sweden: A Cluster-randomized Trial	N/A
Completed	`NCT01333098` - Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders	Phase 1/Phase 2