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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06373926
Other study ID # PI2019_843_0010
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date March 28, 2023
Est. completion date March 2025

Study information

Verified date April 2024
Source Centre Hospitalier Universitaire, Amiens
Contact Valéry Salle, MD
Phone 03 22 66 82 30
Email salle.valery@chu-amiens.fr
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Annexin A2 (ANXA2), an endothelial cell receptor for plasminogen and tissue plasminogen activator, plays a pivotal role in regulation of fibrinolysis in vitro and in vivo and has been identified as a new autoantigen in antiphospholipid syndrome (APS). ANXA2 can exist as a monomer or a heterotetrameric complex with S100A10 protein. The aim of this study was to evaluate the cell membrane expression of ANXA2 on circulating monocytes in APS by flow cytometry. Several pathogenic mechanisms are involved in APS such as activation of endothelial cells, platelets and monocytes, inhibition of the natural anticoagulant protein C/protein S pathway, activation of the complement system and also impairment of fibrinolysis. Annexin A2 which hits binding partner S100A10, ANXA2 forms a cell surface complex that regulates generation of plasmin. ANXA2 is involved in the pathogenesis of APS-associated through several possible mechanisms. Human peripheral blood monocytes represent the major circulating ANXA2-expressing cell and ANXA2-mediated assembly of plasminogen and tissue activator of plasminogen (tPA) on monocyte/macrophages contributes to plasmin generation. Thus the investigators could suppose that decrease of cell membrane expression of ANXA2 on circulating monocytes represent a new pathogenic mechanism in APS.


Recruitment information / eligibility

Status Recruiting
Enrollment 60
Est. completion date March 2025
Est. primary completion date March 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - APS patients who fulfilled the revised criteria for APS Exclusion Criteria: - Patients less than 18 years old - Solid and hematological malignancies - Other autoimmune diseases - Cirrhosis

Study Design


Related Conditions & MeSH terms


Intervention

Biological:
blood withdrawal
blood withdrawal

Locations

Country Name City State
France CHU Amiens Amiens

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Cell membrane expression rate of ANXA2 on circulating monocytes in APS 1 hour
Secondary Cellular expression of ANXA2 and S100A10 in APS patients 1 hour
Secondary cell membrane expression of ANXA2 and S100A10 in APS patients 1 hour
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