Antibiotic Clinical Trial
Official title:
Non-interventional Observational Study of Daptomycin in the Treatment of Gram-positive Bacterial Infections
This study aims to collect and analyze clinical data of daptomycin to explore the efficacy and safety of daptomycin in the treatment of Gram-positive bacterial infections. And optimize the dosing regimen based on these data.
With the gradual increase in the detection rate of drug-resistant bacteria, bloodstream
infections, skin and soft tissue infections, infective endocarditis and other infectious
diseases caused by MRSA, MRCNS, and VRE have greatly increased patient mortality and medical
burden.
Daptomycin has strong anti-bacterial activity and rapid sterilization. It is almost 100%
sensitive to common Gram-positive bacteria. Both domestic and foreign guidelines recommend
its use for the treatment of infectious diseases such as bacteremia, central venous
catheter-related bloodstream infections, infective endocarditis, skin and soft tissue
infections, bone and joint infections，and so on. However, there is a lack of actual clinical
use of daptomycin in China, as well as efficacy and safety assessments based on real world
data.
The purpose of this study is to collect and analyze data on the use of daptomycin in the real
world. The clinical cure rate and inefficiency, temperature drop time, 28-day mortality rate
are the primary outcome measures, and the overall incidence of adverse events, the results of
CPK monitoring and its correlation with dose, renal function, length of hospital stay, and
treatment costs are secondary outcome measures to investigate the efficacy and safety of
daptomycin in the treatment of gram-positive bacterial infection.
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