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NCT03790254 Clinical Trial

D Mannose for Prevention and Treatment of RUTIs

Antibiotic Prophylaxis Clinical Trial

— mannoseRUTIs  

Official title:
Oral D Mannose in the Prevention and Treatment of Recurrent Urinary Tract Infections: a Systematic Review

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03790254
Other study ID # ReviewUTIs
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2010
Est. completion date December 25, 2018

Study information
Verified date December 2018
Source IRCCS Policlinico S. Matteo
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of this review is to address clinical reliability, efficacy and safety of long-term treatment with oral D Mannose for the prevention of recurrent urinary tract infections (RUTIs) in females.

Description:

A comprehensive systematic MEDLINE, Embase, Cochrane search was performed for English language reports published before December 2018 using the term "recurrent urinary tract infections and d mannose." We searched Medline, Embase, and the Cochrane Register of Controlled Trials since January 2010 to December 2018. Eligible studies did not include non-oral therapy, local (vaginal) treatment in women with RUTIs.

Study eligibility criteria- We identified eligible original articles. The heterogeneity of the available studies, their different rationale and aim, the assumption of d mannose for prophylaxis or treatment of recurrent UTIs need to be taken into account.

Recruitment information / eligibility
Status Completed
Enrollment 500
Est. completion date December 25, 2018
Est. primary completion date December 20, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years to 90 Years
Eligibility Inclusion Criteria:

recurrent urinary tract infections (RUTIs)

Exclusion Criteria:

Upper urinary tract infections, severe clinical symptoms, fever > 37,5 with lumbar pain

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• systematic review

Locations
Country Name City State
Italy Urology Department Fondazione IRCCS Policlinico San Matteo Pavia

Sponsors (1)
Lead Sponsor Collaborator
IRCCS Policlinico S. Matteo

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary research literature data on d mannose for prevention and treatment of recurrent urinary tract infections. literature search of the Medline, Embase, and Cochrane Library databases January 2010-December 2018
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