Antibiotic Prophylaxis Clinical Trial
Official title:
Prophylactic Antibiotic Use in Transarterial Chemoembolization for Hepatocellular Carcinoma: an Open-label, Randomised, Prospective Study
This study aims to determine the effectiveness of prophylactic antibiotic use for TACE and occurrence of postoperative liver abscess. There would be two comparison groups. Current standard of care treatment at PKLI&RC (as per local guidelines) would be given to all patients receiving TACE for the intervention group or 'antibiotic group' (i.e., Inj. Ceftriaxone 1g, intravenous × stat). While no antibiotic would be given to the 'no antibiotic group'.
Liver cancer especially hepatocellular carcinoma (HCC) is among the top five most common carcinomas in the world. According to the latest Cardiovascular and Interventional Radiological Society of Europe (CIRSE) standards of practice guidelines (2021), routine antibiotic prophylaxis is not recommended. However, prophylactic antibiotics are recommended in cases where there is a high risk of developing a liver abscess. These include biliary obstruction or the presence of a bilioenteric anastomosis. This study aims to determine the effectiveness of prophylactic antibiotic use for TACE and occurrence of postoperative liver abscess. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03028129 -
Prevention of Tuberculosis in Prisons
|
Phase 4 | |
| Completed |
NCT05612542 -
Pediatric Cardiac Surgery Comparing Short 24-hour Antibiotic Prophylaxis to Extended Antibiotic Prophylaxis
|
||
| Completed |
NCT03765645 -
Comparison of 9 Doses vs 3 Doses of Post Operative Antibiotics in Live Liver Donors
|
N/A | |
| Completed |
NCT03306290 -
Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery
|
N/A | |
| Recruiting |
NCT03283878 -
Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial
|
Phase 4 | |
| Not yet recruiting |
NCT05438082 -
Antibiotic Prophylaxis to Prevent Post-procedure UTI After VCUG
|
Phase 4 | |
| Recruiting |
NCT05609240 -
Colo-Pro_2: Bolus-continuous Infusion Cefuroxime Prophylaxis for the Prevention of Infections After Colorectal Surgery
|
Phase 2 | |
| Withdrawn |
NCT04280237 -
Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation
|
||
| Completed |
NCT02479503 -
Antibiotic Prophylaxis in Adult Heart Transplantation: a French National Survey
|
||
| Completed |
NCT00818766 -
Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy.
|
N/A | |
| Recruiting |
NCT05755789 -
Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery
|
Phase 3 | |
| Withdrawn |
NCT01880112 -
Serum and Tissue Cefazolin Concentrations in Normal Weight Patients Undergoing Cesarean Delivery.
|
Phase 4 | |
| Withdrawn |
NCT03982810 -
The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery.
|
||
| Recruiting |
NCT03269604 -
Effectiveness of Three Times of Starting Antibiotic Prophylaxis in Patients With Asymptomatic Bacteriuria.
|
N/A | |
| Terminated |
NCT03386227 -
Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT
|
N/A | |
| Completed |
NCT02809729 -
Antibiotic Prophylaxis in Oncological Surgery of Breast
|
N/A | |
| Completed |
NCT03412305 -
The Effect of Antibiotic Prophylaxis Associated With Dental Implant Surgery
|
Phase 4 | |
| Completed |
NCT03790254 -
D Mannose for Prevention and Treatment of RUTIs
|
||
| Recruiting |
NCT05519072 -
Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA
|
Phase 4 | |
| Not yet recruiting |
NCT05813184 -
Prenatal Antibiotics and Breast Milk / Neonatal IgA
|