Hematologic Diseases Clinical Trial
To determine the therapeutic effects of anti-thymocyte globulin (ATG) in patients with aplastic anemia and related bone marrow failure diseases.
BACKGROUND:
Aplastic anemia has been shown to respond to ATG. An immunological basis for aplastic anemia
has been suggested by previous observations although the precise mechanism of action of ATG
has not been defined. This serum, produced by immunization of horses with human thymocytes,
may have broad reactivity with many human cells.
DESIGN NARRATIVE:
Patients in Group I with acute severe disease were randomized to receive ATG in either ten
day or twenty-eight day courses. Patients in Group II with moderate or chronic disease were
randomized to receive either ATG for ten days or high doses of the androgen, nandrolone
decanoate. Patients in Group III with a variety of bone marrow diseases were also treated
with ATG.
The study completion date listed in this record was inferred from the last publication
listed in the Citations section of this study record.
;
Allocation: Randomized, Primary Purpose: Treatment
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