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Effect of dRAST on Treatment for Bacteremia in Patients With Hematologic Diseases

Hematologic Diseases Clinical Trial

Official title:
Effect of Direct Rapid Antibiotic Susceptibility Testing (dRAST) on Treatment for Bacteremia in Patients With Hematologic Diseases: Randomized Controlled Trial

Clinical Trial Summary

The purpose of this study is to evaluate whether the use of direct rapid antibiotic susceptibility test (dRAST), in addition to the current standard antibiotic susceptibility test, can increase the proportion of patients with hematologic disease who received appropriate antibiotics in early period of bacteremia.

Clinical Trial Description

- patients with hematologic diseases who have high risk of bacteremia, because of immune suppression treatment or intensive chemotherapy or bone marrow transplantation which these patients had received, will be recruited in tertiary referral medical centers.

- All the participants will be randomly assigned into either dRAST group or current standard antibiotic susceptibility test group.

- All the participants in the both arms will receive antimicrobial stewardship by infectious disease specialists. Antimicrobial stewardship will be performed at each timepoint of Gram stain results reporting, dRAST results reporting, and current method reporting.

- Target numbers are 58 and 58, respectively.

- All the participants will be monitored for general medical conditions such as vital sign and response to antibiotic treatment by infectious disease specialists for 1 week.

- The percentage of patients who received optimal targeted antibiotics 72 hours after blood collection for blood culture will be evaluated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03611257
Study type Interventional
Source Seoul National University Hospital
Contact
Status Completed
Phase N/A
Start date September 1, 2018
Completion date October 10, 2019
View Details
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