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Amyloidosis clinical trials

View clinical trials related to Amyloidosis.

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NCT ID: NCT04769479 Completed - Amyloidosis Clinical Trials

A Single Dose Study to Evaluate the Pharmacokinetics of Acoramidis Modified Release Formulations in Healthy Subjects

Start date: March 28, 2021
Phase: Phase 1
Study type: Interventional

This is a single centre, open-label, 5-period study in healthy male and non-pregnant and non-lactating healthy female subjects.

NCT ID: NCT04659798 Completed - Multiple Myeloma Clinical Trials

A Study to Investigate the Relationship Between Duration of Treatment and Response in Patients With Multiple Myeloma (MM) or Systemic AL Amyloidosis Treated in Real-life Practice

DOrianT
Start date: January 22, 2021
Phase:
Study type: Observational

The study will provide information on outcomes in people with multiple myeloma, or systemic AL amyloidosis, or both, under standard care. AL is short for amyloid light-chain. Standard care means the participant will be treated according to their clinic's standard practice. The study sponsor will not be involved in how participants are treated but will provide instructions on how the clinics will record what happens during the study. The aim of the study is to learn if treatment duration makes a difference in how participants with multiple myeloma or systemic AL amyloidosis respond to their treatment. During the study, participants will be treated according to their clinic's standard practice. Participants must have started their treatment up to 12 months before taking part in this study. During the study, the participants will visit their clinic every 3 months. These are extra visits to their clinic's standard visits.

NCT ID: NCT04615572 Completed - Clinical trials for Smoldering Multiple Myeloma

Screening to Improve Survival in AL Amyloidosis

Start date: August 28, 2020
Phase:
Study type: Observational

The purpose of this study is to see whether certain genes may be linked with the development of AL amyloidosis in subjects 60 years of age or older with the blood disorders SMM and MGUS. A limited repertoire of immunoglobulin (Ig) variable region genes have been associated with AL amyloidosis. The clonal plasma cells of subjects with SMM and MGUS may express one of these Ig variable region genes indicating a risk of progression to AL amyloidosis and potentially enabling early diagnosis. We hope this study will help us begin to understand whether Ig variable region gene identification can be a useful tool for assessing a subject's risk of progression to AL amyloidosis.

NCT ID: NCT04421040 Completed - Clinical trials for TTR Cardiac Amyloidosis

Long-term Monitoring of Patients With Cardiac Amyloidosis With Implantable Event Monitors

Start date: October 7, 2020
Phase: N/A
Study type: Interventional

Researchers are gathering information to see if using an FDA approved implantable device can help with monitoring of your heart arrhythmias.

NCT ID: NCT04360434 Completed - Clinical trials for Amyloid Transthyretin Cardiomyopathy

First-in-Human Study of NI006 in Patients With Amyloid Transthyretin Cardiomyopathy

Start date: February 10, 2020
Phase: Phase 1
Study type: Interventional

A phase 1, randomized, placebo-controlled, double-blind, dose escalation trial combining single-ascending dose and multiple-ascending dose phases of NI006 or placebo, followed by an open-label extension phase in subjects with Amyloid Transthyretin Cardiomyopathy (ATTR-CM).

NCT ID: NCT04304144 Completed - AL Amyloidosis Clinical Trials

A Study to Evaluate the Safety and Tolerability of CAEL-101 in Patients With AL Amyloidosis

Start date: March 18, 2020
Phase: Phase 2
Study type: Interventional

AL amyloidosis begins in the bone marrow where abnormal proteins misfold and create free light chains that cannot be broken down. These free light chains bind together to form amyloid fibrils that build up in the extracellular space of organs, affecting the kidneys, heart, liver, spleen, nervous system and digestive tract. The primary purpose of this study is to determine the recommended dose of CAEL-101 to facilitate progression of further clinical trials and evaluate safety and tolerability of CAEL-101 in combination with the standard of care (SoC) cyclophosphamide-bortezomib-dexamethasone (CyBorD) chemotherapy and daratumumab .

NCT ID: NCT04298372 Completed - Amyloidosis Cardiac Clinical Trials

Frontline Lenalidomide for AL Amyloidosis Involving Myocardium

Start date: February 20, 2019
Phase: Phase 3
Study type: Interventional

This phase II clinical trial aimed at influencing the improvement of major organ functions, especially the objective response rate, in Amyloid light-chain amyloidosis involving myocardium.

NCT ID: NCT04242667 Completed - Cancer Clinical Trials

Penn Biobank Return of Research Results Program

Start date: March 1, 2020
Phase: N/A
Study type: Interventional

The overall goal of the proposed research is to assess the feasibility of a randomized study evaluating the non-inferiority of an electronic Health (e-Health) delivery alternative (e.g. private web portal) as compared to return of actionable genetic research results with a genetic counselor.

NCT ID: NCT04201418 Completed - Polyneuropathy Clinical Trials

A Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients With Polyneuropathy of ATTRv Amyloidosis With a V122I or T60A Mutation

Start date: December 18, 2019
Phase:
Study type: Observational

To evaluate the effectiveness of patisiran in patients with ATTRv amyloidosis with polyneuropathy who have a V122I or T60A mutation.

NCT ID: NCT04160351 Completed - Quality of Life Clinical Trials

A Randomised, Open-Label, Cross Over Group, Single-Centre Controlled Study To Evaluate The Clinical Performance Of Medium Cut-Off Membrane Dialyser Compared With High Flux Dialyser Among Patients With Chronic Haemodialysis

HD-1
Start date: December 1, 2019
Phase: N/A
Study type: Interventional

This is an open label, cross-over group, single-centre randomised controlled trial comparing Medium Cut Off Dialyser with High Flux Dialyser in patients with end-stage renal disease on chronic haemodialysis.