PET Study of Acetylcholine Esterase Activity in Alzheimer's Disease

Alzheimer Disease Clinical Trial

Official title:

PET Study of Acetylcholine Esterase Activity in Alzheimer's Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06180252
• Other study ID #: MP4-FIN2001
• Status: Completed
• Start date: May 12, 2004
• Est. completion date: January 29, 2008

Study information

• Verified date: December 2023
• Source: IRCCS San Raffaele
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to understand regional variations in acetylcholine esterase activity in Alzheimer's disease. In this study the aim is to identify by PET the physiological values of the regional activity of acetylcholine esterase using the 11C PM4 tracer and to study by PET and 11C PM4 the brain activity of acetylcholine esterase in a group of patients with Alzheimer's disease, enrolled according to the inclusion and exclusion criteria. The PET data will be correlated with the clinical, neuropsychological and morphological data acquired by MRI and with the clinical-cognitive outcome.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: January 29, 2008
• Est. primary completion date: January 29, 2008
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients diagnosed with Alzheimer's disease;
• patients must have undergone an instrumental morphological examination to exclude other neurological pathologies.

Exclusion Criteria:

• positive history of major head trauma;
• clinically active somatic diseases.

Related Conditions & MeSH terms

• Alzheimer Disease

Intervention

Diagnostic Test:
• PET with 11C MP4
Each subject will undergo a PET exam using 11C MP4 as a tracer. This is a specific ligand for the acetyl-choline esterase enzyme already used abroad both in healthy volunteers and in various patient groups.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
IRCCS San Raffaele

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	PET with 11C MP4 as a tracer to identify acetylcholine esterase values in patients with neurodegenerative diseases.	Development of a new PET method for the in vivo measurement of acetylcholine esterase activity at the cortical level to be used as an indicator of the presence of disease.	4 years