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Alteration of Cognitive Function clinical trials

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NCT ID: NCT02958735 Completed - Clinical trials for Alteration of Cognitive Function

Exercise and Cognition Trials

EXACT
Start date: August 1, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether an acute bout of exercise may temporarily enhance cognitive function (such as memory or attention span) by measuring behavioral performance on cognitive tests, as well as expression of hormones in circulation associated with brain plasticity and stress.

NCT ID: NCT02884050 Completed - Clinical trials for Alteration of Cognitive Function

Physiologic Effects of Topiramate on Cognition

Start date: April 2009
Phase: Phase 1
Study type: Interventional

Data generated from this pilot project will be used to support a larger, NIH funded study to investigate the physiologic mechanisms associated with the cognitive side effects of a commonly prescribed antiepileptic drug (AED), topiramate (TPM). This study will provide pilot data to 1) demonstrate the viability of using quantitative electroencephalogram (EEG) to examining physiological effects of AEDs as they relate to language function, and 2) perform formal power estimate calculations in support of a longer-term connectivity study using stochastic modeling techniques including power, coherence, and Granger causality metrics to analyze AED effects on quantitative EEG. Traditionally, the cognitive side effects of AEDs have been considered a byproduct of decreased neuronal excitation associated with medical therapy, although recent data suggests that this may not be true for some newer medications, such as TPM. The proposed experiments will employ quantitative EEG to investigate the effects of topiramate on neuronal network connectivity and pharmacokinetic/pharmacogenetic relationships in order to explore individual physiological responses. Topiramate is selected because of its relatively unique effects on generative verbal fluency, but unlike older AEDs, TPM is associated with little EEG change. The investigators will compare the effects of TPM to baseline and an inactive placebo in a randomized double blind crossover design.

NCT ID: NCT02847793 Completed - Depression Clinical Trials

Attentional Bias Modification Through Eye-tracker Methodology (ABMET)

ABMET
Start date: April 1, 2016
Phase: N/A
Study type: Interventional

Cognitive biases are a hallmark of depression but there is scarce research on whether these biases can be directly modified by using specific cognitive training techniques. The aim of this study will be targeting and modifying specifically relevant attention biases in participants with subclinical depression using eye-tracking methodologies. This innovative approach has been proposed as a promising future line of intervention in Attention Bias Modification procedures (Koster & Hoorelbeke, 2015). Recent findings suggest that depression is characterized by a double attentional bias (Duque & Vazquez, 2015), More specifically, depressed individuals have difficulties both to disengage from negative materials (e.g., sad faces) and to engage with positive materials (e.g., happy faces). Thus, training procedures to change attentional biases should target these two separate components.

NCT ID: NCT02486328 Completed - Clinical trials for Gastrointestinal Dysfunction

The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy

Start date: May 2015
Phase: Phase 4
Study type: Interventional

There are different sedation regimes for lower gastrointestinal system endoscopy which can be administered by anesthesiologists and non-anesthesiologists. This study aims to compare the effects of propofol/remifentanil combination and midazolam/meperidine combination on early cognitive function following lower gastrointestinal system endoscopies.

NCT ID: NCT02300272 Completed - Ageing Clinical Trials

Health Behaviors and Time-of-Day: Older Adult Cognitive Function

OA-TIME
Start date: March 2015
Phase:
Study type: Observational

This is a single-center, observational study design. Enrolled participants will be typically, healthy older adults. Participants will complete daily computerized measures, in addition to continuously wearing an Actiwatch device. The study period will last 2 weeks. The objectives of the study are to examine the impact of sleep, pain, and circadian rhythm on practice-related learning in older adults at their preferred versus nonpreferred times of day.

NCT ID: NCT02270320 Completed - Clinical trials for Alteration of Cognitive Function

Cognitive Effects of Tai Chi Chuan in Healthy Older Adults and Older Adults

Start date: January 2014
Phase: N/A
Study type: Interventional

Background: Promotion of cognitive functions of middle aged and older adults and prevention of dementia are important issues in the aging society. In recent years, studies have shown that Tai Chi Chuan (TCC) exercise can improve cognitive functions in healthy middle-aged and older adults, but not studies have investigated the neural mechanisms. Therefore, the purposes of this research project are: (1) to investigate the effects of TCC exercise intervention on improving cognitive functions and motor functions in healthy middle-aged and older adults; (2) to investigate the effects of TCC intervention on improving the integrity of frontostriatal fiber tracts, and areas and intensity of brain activation while performing a switching task in healthy middle-aged and older adults. Methods: This project used the assessor-blind and randomized control clinical trial design. A total of 60 healthy middle-aged and older adults will be recruited, randomly allocated to two groups: experimental and control groups. Experimental group will receive a 60-minute exercise program, three times per week for 12 weeks. Control group will receive a telephone consultation once every two weeks for 12 weeks. All participants will receive clinical neuropsychological tests, Cambridge Neuropsychological Test Automated Battery tests, motor function tests, diffusion spectrum MR imaging, and functional MRI experiments before intervention, and at the end of intervention to realize the changes of cognitive function, motor function, integrity of neural tracts, and intensity and regions of functional activation while doing switching task of executive function in order to understand the cognitive effects and the neural mechanisms of TCC.

NCT ID: NCT01711008 Completed - Clinical trials for Alteration of Cognitive Function

The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women

Start date: September 2012
Phase: N/A
Study type: Interventional

Both regular exercise and breakfast consumption have well known health benefits. Consuming breakfast prior to morning exercise may influence appetite, mood and cognitive function later in the day. The purpose of this study is to test whether the amount of food consumed at breakfast prior to exercise influences these parameters in active women.

NCT ID: NCT01555996 Completed - Delirium Clinical Trials

Early Occupational Therapy for Delirium Prevention in Older Patients Admitted to Critical Care Unit

Start date: April 2011
Phase: N/A
Study type: Interventional

This is a randomized, controlled trial to compare the efficacy of two strategies of non-pharmacological prevention of delirium in critically non-ventilated older patients: - standard non-pharmacological prevention - intensive nonpharmacological prevention (standard non-pharmacological prevention plus early and intensive occupational therapy).

NCT ID: NCT01429103 Completed - Clinical trials for Alteration of Cognitive Function

Hormones and Cognition in the Menopausal Transition

Start date: May 2011
Phase: N/A
Study type: Observational

The purpose of this study is to determine if the menopausal transition is associated with subjective and objective cognitive declines that ameliorate in menopause. The investigators hypothesize that perimenopause is associated with both subjective memory complaints and objective declines in attentionally mediated cognitive tasks. The investigators also hypothesize that this is time-limited. The investigators predict that as women transition from early perimenopause to late perimenopause their performance on attentionally mediated and verbal memory tasks will decline, and that as they transition from late perimenopause to menopause, their performance will improve.

NCT ID: NCT01012947 Completed - Clinical trials for Dietary Modification

Cognitive Health Promotion Project in the Community

Start date: February 2008
Phase: Phase 1
Study type: Interventional

This study was based on baseline data derived from a large prospective study called the Suwon Project (SP), a cohort comprising random clustering samples of elderly people, all of whom are ethnic Koreans aged over 60 years.