The Effect of Resistance Exercise on Inflammation in Young and Older Adults

Aging Clinical Trial

Official title:

The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05042167
• Other study ID #: 202012HM020
• Status: Completed
• Phase: N/A
• Start date: October 1, 2021
• Est. completion date: December 31, 2022

Study information

• Verified date: January 2023
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: December 31, 2022
• Est. primary completion date: December 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Age: 20-80

• Healthy male

• Without experience of resistance training

Exclusion Criteria:

• No acute or chronic musculoskeletal symptoms

• Smoking

• Alcohol or drug abuse

• Fail to conduct resistance exercise

Related Conditions & MeSH terms

• Aging
• Inflammation
• Inflammatory Response

Intervention

Other:
• Resistance exercise
4 total resistance exercises that target all major muscle groups.

Locations

Country	Name	City	State
Taiwan	National Taiwan Normal University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in biomarkers of inflammation	Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-a in pg/mL.	24-hour during each study intervention
Secondary	Changes in glucose	glucose in mg/dL	24-hour during each study intervention
Secondary	Changes in metabolic parameters	Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL.	24-hour during each study intervention
Secondary	Changes in biomarkers of muscle damage	Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.	24-hour during each study intervention
Secondary	Changes in molecular markers in peripheral blood mononuclear cells (PBMC)	Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units.	24-hour during each study intervention
Secondary	Changes in complete blood count (CBC)	The white blood cell count and the count of each white blood cell type will be measured.	24-hour during each study intervention
Secondary	Borgs Ratings of Perceived Exertion (RPE)	Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).	1-hour during each exercise intervention