Aging Clinical Trial
Official title:
Improving Everyday Functioning in Adults Aged 70 and Over Using a Multivitamin Supplement
Investigation of the chronic effect of 12 week multivitamin supplementation on markers of everyday function in adults aged 70 and over.
Everyday functioning relates to how well an individual can function independently in
day-to-day life. As a person ages, there are various changes which occur in the body, which
can lead to a decline in everyday functioning. There is a loss of bone density, the immune
system naturally declines which can lead to a susceptibility to autoimmune diseases,
infection and cardiovascular disease. Many older adults report feeling socially isolated and
lonely, which can also lead to poor mood and negative health outcomes. Due to advancements in
society, there has been an increase in older adult informal caregivers, which is a form of
chronic stress associated with a range of negative outcomes and declines in functioning.
Nutritional supplementation may have the potential to improve everyday functioning in older
adults, which may have declined through ageing alone or ageing alongside chronic stress from
being a caregiver. Research had shown multivitamin supplementation to have positive
cognitive, mood, mobility and health effects. As well as improving general day-to-day
well-being and functioning, and may have the ability to reduce feeling of stress.
The current study will investigate the effects of a multivitamin supplement following daily
intake for 12 weeks on a range of everyday functioning outcomes in adults aged 70 and over.
The outcome measures include; well being, cardiovascular reactivity, immune response, stress,
self-reported health, daily functioning behaviours, mobility, mood, cognitive function, sleep
quality and loneliness.
Amendment to protocol:
The recent Covid-19 restrictions have led to changes to the original protocol. Specifically,
a group of participants who completed their baseline assessment as per the outlined protocol
could not complete the final testing visit as initially planned because of the imposed
lockdown For these participants, all follow-up questionnaire-based assessments have been
conducted online from their home.
These necessary changes to the method of data collection will be a confounding factor in this
group, which would not be comparable to the main dataset. Therefore, the decision has been
made to un-blind the researcher to this group of participants' treatment (11 who completed in
full prior and 34 who completed testing visit 2 online).
This will allow the main outcome measures to be compared in this unique group of
participants', as well as comparisons between outcome measures in those who completed pre and
during lockdown.
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