Aging Clinical Trial
— CoQ10SportOfficial title:
Bioavailability and Impact of the Administration of Coenzyme Q10, on Mitochondrial Function Associated With Exercise Under Stress Conditions in Physically Active Individuals of Senescence Age
Verified date | March 2019 |
Source | Centre d'Alt Rendiment |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
It is proposed to establish a group of subjects composed of 10 healthy individuals of> 50 years and <65, physically active, without metabolic or inflammatory pathology. All of them will undergo a health examination and the physical condition and the absence of contraindication of the sports practice will be characterized through a monitored effort test. Each subject will take a capsule of coenzyme Q10® INDENA for 30 days. The dose to be administered is 100 mg/d of CoQ10 a with food (noon). The state of physical condition and the biochemical and biological variables that reflect oxidative stress and mitochondrial functioning before and after the intervention will be measured.
Status | Completed |
Enrollment | 22 |
Est. completion date | February 28, 2019 |
Est. primary completion date | May 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years to 65 Years |
Eligibility |
Inclusion criteria - Athletes over 50 active at this time - Runners - Without medical treatment - Without acute or chronic inflmatory disease - No recent infectious processes - No muscle or joint injuries in the last 6 months - Stable training during the evaluation period - Without taking supplementation Exclusion criteria - Injuried, sickness, during the study - Lack of compromise - Inflamatory process - Abandon the training by any reason |
Country | Name | City | State |
---|---|---|---|
Spain | Centre D'Alt Rendiment, Sant Cugat | Sant Cugat Del Vallés | Barcelona |
Lead Sponsor | Collaborator |
---|---|
Centre d'Alt Rendiment | Hospital Sant Joan de Deu, Indena S.p.A, University of Barcelona |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in the concentration of CoQ10 on different tissues after supplementation for a month | Evaluate the change in the concentration of CoQ10 on plasma, muscle, monouclear cells and urinary epithelium, by specific analysis of every sample tissue at the Pathology Dept and the Methabolopathies Dept of the Pediatric Hospital of Sant Joan de Deu | 6 months | |
Secondary | Effect of the CoQ10 supplementation on the oxidative response to stressing exercise under heat and humidity | Determination of the inflammatory response before and after stressing exercise at the climate chamber at 35ºC and 55% humidity. The procedure is by the analysis of the venous blood extracted previous the exercise stress and 30 minutes after the period of work | 3 months | |
Secondary | Effect of the CoQ10 supplementation on the inflammatory response to stressing exercise under heat and humidity | Determination of the Total antioxidant capacity before and after stressing exercise at the climate chamber at 35ºC and 55% humidity. The procedure is by the analysis of the venous blood extracted previous the exercise stress and 30 minutes after the period of work | 3 months |
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